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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B12
All Species:
33.64
Human Site:
Y220
Identified Species:
61.67
UniProt:
Q53GQ0
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53GQ0
NP_057226.1
312
34324
Y220
S
Q
C
L
H
E
E
Y
R
S
K
G
V
F
V
Chimpanzee
Pan troglodytes
XP_001158375
312
34320
Y220
S
Q
C
L
H
E
E
Y
R
S
K
G
V
F
V
Rhesus Macaque
Macaca mulatta
XP_001113903
312
34903
F220
R
Q
N
Y
Y
K
Q
F
D
W
L
G
T
F
T
Dog
Lupus familis
XP_848504
312
34370
Y220
S
R
C
L
H
E
E
Y
R
S
K
G
I
F
V
Cat
Felis silvestris
Mouse
Mus musculus
O70503
312
34723
Y220
S
Q
C
L
H
E
E
Y
K
S
K
G
I
F
V
Rat
Rattus norvegicus
Q6P7R8
312
34822
Y220
S
Q
C
L
H
E
E
Y
K
S
K
G
I
F
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJG8
331
37589
Y236
S
R
A
L
Y
Y
E
Y
A
S
K
G
I
F
V
Frog
Xenopus laevis
Q8AVY8
318
34842
Y225
S
R
G
L
H
A
E
Y
R
S
K
G
V
T
V
Zebra Danio
Brachydanio rerio
Q6P3L6
319
35532
Y226
S
R
G
L
Q
T
E
Y
K
C
K
G
I
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572420
321
35098
Y224
S
D
D
L
Q
T
E
Y
K
E
H
G
I
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09517
316
34290
Y220
T
A
I
L
R
K
E
Y
E
H
Q
G
I
T
V
Sea Urchin
Strong. purpuratus
XP_001179990
285
31136
V194
K
R
G
I
I
I
N
V
S
S
A
S
G
M
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RYE5
332
36765
L227
S
S
A
L
S
A
E
L
K
D
Q
G
V
D
V
Conservation
Percent
Protein Identity:
100
99.6
85.9
85.5
N.A.
81
81.7
N.A.
N.A.
42.9
61.6
59.2
N.A.
44.2
N.A.
38.6
46.7
Protein Similarity:
100
99.6
90
93.9
N.A.
90
90
N.A.
N.A.
60.1
77.3
74.6
N.A.
63.8
N.A.
55.7
65
P-Site Identity:
100
100
20
86.6
N.A.
86.6
86.6
N.A.
N.A.
60
73.3
40
N.A.
33.3
N.A.
33.3
6.6
P-Site Similarity:
100
100
46.6
100
N.A.
100
100
N.A.
N.A.
80
80
66.6
N.A.
53.3
N.A.
60
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.3
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
56
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
16
0
0
16
0
0
8
0
8
0
0
0
0
% A
% Cys:
0
0
39
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
0
0
0
8
8
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
39
85
0
8
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
54
0
% F
% Gly:
0
0
24
0
0
0
0
0
0
0
0
93
8
0
0
% G
% His:
0
0
0
0
47
0
0
0
0
8
8
0
0
0
0
% H
% Ile:
0
0
8
8
8
8
0
0
0
0
0
0
54
8
16
% I
% Lys:
8
0
0
0
0
16
0
0
39
0
62
0
0
0
0
% K
% Leu:
0
0
0
85
0
0
0
8
0
0
8
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
39
0
0
16
0
8
0
0
0
16
0
0
0
0
% Q
% Arg:
8
39
0
0
8
0
0
0
31
0
0
0
0
0
0
% R
% Ser:
77
8
0
0
8
0
0
0
8
62
0
8
0
0
0
% S
% Thr:
8
0
0
0
0
16
0
0
0
0
0
0
8
16
8
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
0
31
0
70
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
8
16
8
0
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _