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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHL22
All Species:
5.15
Human Site:
S393
Identified Species:
12.59
UniProt:
Q53GT1
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53GT1
NP_116164.2
634
71667
S393
Q
Q
E
H
A
D
L
S
V
C
V
V
G
R
Y
Chimpanzee
Pan troglodytes
XP_514994
557
63055
Y323
S
V
C
V
V
G
R
Y
I
Y
A
V
A
G
R
Rhesus Macaque
Macaca mulatta
XP_001083348
634
71664
S393
Q
Q
E
H
A
D
L
S
V
C
V
V
G
R
Y
Dog
Lupus familis
XP_543559
634
71721
C393
Q
Q
E
H
A
D
L
C
V
C
V
V
G
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q99JN2
634
71668
C393
Q
Q
E
H
A
D
L
C
V
C
V
V
G
K
Y
Rat
Rattus norvegicus
Q66HD2
613
69917
K377
P
R
R
K
Q
W
I
K
V
A
S
M
N
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZLD3
629
70952
N393
F
R
F
D
P
R
Y
N
K
W
M
Q
V
A
S
Frog
Xenopus laevis
NP_001086711
635
71326
G368
Q
H
G
I
A
V
I
G
N
F
L
Y
V
V
G
Zebra Danio
Brachydanio rerio
Q5RGB8
605
68516
V370
Y
R
S
G
E
G
A
V
D
I
C
F
R
Y
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUU5
623
68905
G363
S
K
R
R
C
G
V
G
V
A
V
L
N
D
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.6
99.8
98.4
N.A.
94.6
34.3
N.A.
N.A.
34.2
34.1
32
N.A.
28.7
N.A.
N.A.
N.A.
Protein Similarity:
100
87.8
99.8
99.2
N.A.
97.4
52.5
N.A.
N.A.
53.7
53.8
51.4
N.A.
44.7
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
93.3
N.A.
86.6
6.6
N.A.
N.A.
0
13.3
0
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
93.3
N.A.
93.3
33.3
N.A.
N.A.
20
26.6
6.6
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
50
0
10
0
0
20
10
0
10
10
0
% A
% Cys:
0
0
10
0
10
0
0
20
0
40
10
0
0
0
0
% C
% Asp:
0
0
0
10
0
40
0
0
10
0
0
0
0
10
10
% D
% Glu:
0
0
40
0
10
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
10
0
10
0
0
0
0
0
0
10
0
10
0
0
0
% F
% Gly:
0
0
10
10
0
30
0
20
0
0
0
0
40
10
10
% G
% His:
0
10
0
40
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
20
0
10
10
0
0
0
0
0
% I
% Lys:
0
10
0
10
0
0
0
10
10
0
0
0
0
10
0
% K
% Leu:
0
0
0
0
0
0
40
0
0
0
10
10
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
10
0
0
0
20
0
0
% N
% Pro:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
50
40
0
0
10
0
0
0
0
0
0
10
0
10
0
% Q
% Arg:
0
30
20
10
0
10
10
0
0
0
0
0
10
30
20
% R
% Ser:
20
0
10
0
0
0
0
20
0
0
10
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
10
10
10
10
10
60
0
50
50
20
10
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
10
10
0
10
0
10
0
10
40
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _