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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM177
All Species:
6.06
Human Site:
S142
Identified Species:
14.81
UniProt:
Q53S58
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53S58
NP_001098668.1
311
33760
S142
A
G
A
R
L
R
A
S
L
T
L
S
R
E
A
Chimpanzee
Pan troglodytes
XP_001157041
311
33789
S142
A
G
A
R
L
R
A
S
L
T
L
S
R
E
A
Rhesus Macaque
Macaca mulatta
XP_001084260
311
34178
A142
A
G
A
R
L
R
A
A
L
T
L
S
H
E
A
Dog
Lupus familis
XP_533321
875
98723
A706
A
G
T
R
L
R
D
A
L
T
L
S
R
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BPE4
311
34049
A142
A
G
T
R
L
R
D
A
L
T
M
S
H
N
A
Rat
Rattus norvegicus
Q4KM93
311
33983
A142
A
G
T
R
L
R
D
A
L
T
L
S
H
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422081
304
32946
K137
S
N
E
G
V
A
L
K
E
A
L
T
F
S
L
Frog
Xenopus laevis
Q66IS8
310
34180
H142
W
S
S
D
A
G
T
H
L
R
Q
A
L
N
L
Zebra Danio
Brachydanio rerio
Q6PBI8
310
34011
L142
D
S
D
S
G
V
A
L
K
N
S
L
V
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798641
308
34306
S141
L
K
D
S
L
K
L
S
P
A
A
R
R
F
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
91.3
29.4
N.A.
78.4
78.7
N.A.
N.A.
43.7
42.4
42.1
N.A.
N.A.
N.A.
N.A.
27.3
Protein Similarity:
100
99.3
94.8
32.9
N.A.
85.8
86.8
N.A.
N.A.
57.8
62.3
60.4
N.A.
N.A.
N.A.
N.A.
47.9
P-Site Identity:
100
100
86.6
73.3
N.A.
60
66.6
N.A.
N.A.
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
100
93.3
86.6
N.A.
73.3
80
N.A.
N.A.
26.6
20
13.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
60
0
30
0
10
10
40
40
0
20
10
10
0
0
70
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
20
10
0
0
30
0
0
0
0
0
0
20
0
% D
% Glu:
0
0
10
0
0
0
0
0
10
0
0
0
0
30
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
20
0
% F
% Gly:
0
60
0
10
10
10
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
30
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
10
0
10
10
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
70
0
20
10
70
0
60
10
10
0
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
10
0
0
0
20
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
60
0
60
0
0
0
10
0
10
40
0
0
% R
% Ser:
10
20
10
20
0
0
0
30
0
0
10
60
0
10
10
% S
% Thr:
0
0
30
0
0
0
10
0
0
60
0
10
0
0
0
% T
% Val:
0
0
0
0
10
10
0
0
0
0
0
0
10
0
0
% V
% Trp:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _