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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EAPP All Species: 13.64
Human Site: S166 Identified Species: 23.08
UniProt: Q56P03 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q56P03 NP_060923.2 285 32734 S166 H G L G P Q R S R Q Q Q P V P
Chimpanzee Pan troglodytes XP_509897 285 32735 S166 H G L G P Q R S R Q Q Q P V P
Rhesus Macaque Macaca mulatta XP_001104634 296 33316 S177 H G L G L Q R S C Q Q Q P V P
Dog Lupus familis XP_850430 286 32978 Y167 G F G I Q R P Y Q Q Q Q P V P
Cat Felis silvestris
Mouse Mus musculus Q5BU09 281 32475 Q162 G Y H A F G L Q R P R Q K Q Q
Rat Rattus norvegicus NP_001128459 280 32140 R162 Y H A F G L Q R P C Q K Q Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512221 286 33024 S167 H G L R V Q G S H R Q P V V P
Chicken Gallus gallus XP_421235 287 33535 L168 Y R N Q R R V L Q P Q Q T K P
Frog Xenopus laevis NP_001085682 293 33892 Q175 P K Q T H P Q Q S K H Q A M P
Zebra Danio Brachydanio rerio NP_956078 307 34683 R174 L P P S A N R R G K S Q A L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_498165 467 53727 K348 K W V K E H R K I A R G S D A
Sea Urchin Strong. purpuratus XP_001197735 355 39844 A230 K P D K V T G A T C P P S I P
Poplar Tree Populus trichocarpa XP_002307158 149 16865 D31 E F Y D P E L D D K D E L W V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_196449 150 17037 D31 E F Y D S D I D D K D E L W M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 88.1 89.5 N.A. 87.3 87.7 N.A. 74.4 68.9 63.4 61.5 N.A. N.A. N.A. 23.9 41.6
Protein Similarity: 100 99.6 89.8 93.3 N.A. 91.2 91.9 N.A. 82.1 82.2 77.4 73.9 N.A. N.A. N.A. 37.2 59.1
P-Site Identity: 100 100 86.6 40 N.A. 13.3 13.3 N.A. 53.3 20 13.3 20 N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: 100 100 86.6 53.3 N.A. 20 33.3 N.A. 60 40 33.3 33.3 N.A. N.A. N.A. 20 20
Percent
Protein Identity: 28.4 N.A. N.A. 27.7 N.A. N.A.
Protein Similarity: 40 N.A. N.A. 40.3 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 8 0 0 8 0 8 0 0 15 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 15 0 0 0 0 0 % C
% Asp: 0 0 8 15 0 8 0 15 15 0 15 0 0 8 0 % D
% Glu: 15 0 0 0 8 8 0 0 0 0 0 15 0 0 0 % E
% Phe: 0 22 0 8 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 29 8 22 8 8 15 0 8 0 0 8 0 0 0 % G
% His: 29 8 8 0 8 8 0 0 8 0 8 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 8 0 8 0 0 0 0 8 0 % I
% Lys: 15 8 0 15 0 0 0 8 0 29 0 8 8 8 0 % K
% Leu: 8 0 29 0 8 8 15 8 0 0 0 0 15 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % M
% Asn: 0 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 8 15 8 0 22 8 8 0 8 15 8 15 29 0 72 % P
% Gln: 0 0 8 8 8 29 15 15 15 29 50 58 8 15 8 % Q
% Arg: 0 8 0 8 8 15 36 15 22 8 15 0 0 0 0 % R
% Ser: 0 0 0 8 8 0 0 29 8 0 8 0 15 0 0 % S
% Thr: 0 0 0 8 0 8 0 0 8 0 0 0 8 0 0 % T
% Val: 0 0 8 0 15 0 8 0 0 0 0 0 8 36 8 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 15 0 % W
% Tyr: 15 8 15 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _