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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAN3 All Species: 22.42
Human Site: S176 Identified Species: 32.89
UniProt: Q58A45 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q58A45 NP_787050.4 741 82181 S176 S Q V F S H P S M G S P A T A
Chimpanzee Pan troglodytes XP_001136622 741 82148 S176 S Q V F S H P S M G S P A T A
Rhesus Macaque Macaca mulatta XP_001097210 741 82134 S176 S Q V F S H P S M G S P A T A
Dog Lupus familis XP_543150 987 105833 S422 S Q V F S H P S M G S P A A A
Cat Felis silvestris
Mouse Mus musculus Q640Q5 691 76362 T163 A P R R R S H T P N P A S F M
Rat Rattus norvegicus XP_002724835 883 95283 S318 S Q V F S H P S M G S P A T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519591 717 78728 I180 S P L H S P K I T P H T S P A
Chicken Gallus gallus XP_417120 757 83269 S193 Q A L F S H P S M G S P A A A
Frog Xenopus laevis NP_001128699 631 68072 D103 R L S I P G L D A G A I P D T
Zebra Danio Brachydanio rerio XP_002666687 799 86684 F235 P A F A S P I F P H P G L S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728797 788 85176 P180 Q K Q Q Q H P P S V G G G A V
Honey Bee Apis mellifera XP_623553 607 67474 N79 S S S P N L F N N S Y H S Q E
Nematode Worm Caenorhab. elegans P34653 632 71182 G104 G P P T F G P G Q H M N H R A
Sea Urchin Strong. purpuratus XP_796055 760 83393 I195 Q G Q V A S A I P R T N A G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P36102 679 76436 F151 S S S N Y D P F N A P I F T P
Red Bread Mold Neurospora crassa Q7SDP4 656 73993 R128 I F N P A A I R E F T P Q N Y
Conservation
Percent
Protein Identity: 100 99.8 99.7 74.4 N.A. 90.1 82.2 N.A. 80.8 78.3 58.4 68.2 N.A. 38.5 41.8 31.9 49.3
Protein Similarity: 100 100 99.8 74.7 N.A. 90.9 83 N.A. 86 84.1 64 75 N.A. 55.7 59.6 49.5 62.6
P-Site Identity: 100 100 100 93.3 N.A. 0 100 N.A. 20 73.3 6.6 6.6 N.A. 13.3 6.6 13.3 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 20 100 N.A. 33.3 80 13.3 20 N.A. 20 26.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 28
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 45.2
P-Site Identity: N.A. N.A. N.A. N.A. 20 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 13 0 7 13 7 7 0 7 7 7 7 44 19 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 7 0 7 0 0 0 0 0 7 0 % D
% Glu: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % E
% Phe: 0 7 7 38 7 0 7 13 0 7 0 0 7 7 0 % F
% Gly: 7 7 0 0 0 13 0 7 0 44 7 13 7 7 7 % G
% His: 0 0 0 7 0 44 7 0 0 13 7 7 7 0 0 % H
% Ile: 7 0 0 7 0 0 13 13 0 0 0 13 0 0 0 % I
% Lys: 0 7 0 0 0 0 7 0 0 0 0 0 0 0 0 % K
% Leu: 0 7 13 0 0 7 7 0 0 0 0 0 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 38 0 7 0 0 0 7 % M
% Asn: 0 0 7 7 7 0 0 7 13 7 0 13 0 7 0 % N
% Pro: 7 19 7 13 7 13 57 7 19 7 19 44 7 7 7 % P
% Gln: 19 32 13 7 7 0 0 0 7 0 0 0 7 7 0 % Q
% Arg: 7 0 7 7 7 0 0 7 0 7 0 0 0 7 0 % R
% Ser: 50 13 19 0 50 13 0 38 7 7 38 0 19 7 7 % S
% Thr: 0 0 0 7 0 0 0 7 7 0 13 7 0 32 7 % T
% Val: 0 0 32 7 0 0 0 0 0 7 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 0 0 7 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _