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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHG4
All Species:
9.09
Human Site:
Y499
Identified Species:
20
UniProt:
Q58EX7
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58EX7
NP_001123199.1
1191
130803
Y499
Q
G
S
F
Q
E
L
Y
Q
V
A
Q
E
Q
V
Chimpanzee
Pan troglodytes
XP_526816
1617
177550
V851
R
R
G
L
S
A
V
V
S
Q
A
E
C
R
E
Rhesus Macaque
Macaca mulatta
XP_001087633
1210
132988
Y500
Q
G
S
F
R
E
L
Y
E
V
A
Q
E
Q
V
Dog
Lupus familis
XP_546879
1286
140661
D582
K
G
P
F
Q
E
L
D
Q
V
A
Q
E
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
Q3UPH7
1517
165114
S826
E
L
R
F
R
A
F
S
T
E
V
Q
E
R
L
Rat
Rattus norvegicus
Q63406
1149
129391
D472
E
T
S
M
K
W
S
D
E
G
I
F
L
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517639
1384
151393
D615
Q
D
T
F
W
E
L
D
R
A
A
Q
K
H
C
Chicken
Gallus gallus
XP_414038
1260
141915
C495
A
C
I
S
M
E
E
C
S
S
A
E
H
C
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693663
1625
182480
H737
E
D
S
L
E
Q
L
H
H
K
Q
S
I
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_996017
1428
157695
T556
A
Q
R
L
E
Q
L
T
E
Q
R
R
E
R
L
Honey Bee
Apis mellifera
XP_394195
1121
125609
M471
P
E
H
F
T
E
M
M
A
L
A
E
K
L
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
93.8
75.8
N.A.
26.2
23.1
N.A.
45.7
32.2
N.A.
33.6
N.A.
28.3
27.9
N.A.
N.A.
Protein Similarity:
100
40.2
94.9
81.6
N.A.
39.8
41.3
N.A.
56.1
47.3
N.A.
47.6
N.A.
42.6
45
N.A.
N.A.
P-Site Identity:
100
6.6
86.6
80
N.A.
20
6.6
N.A.
40
13.3
N.A.
13.3
N.A.
13.3
20
N.A.
N.A.
P-Site Similarity:
100
33.3
100
86.6
N.A.
46.6
26.6
N.A.
60
20
N.A.
40
N.A.
53.3
46.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
0
0
0
19
0
0
10
10
64
0
0
0
19
% A
% Cys:
0
10
0
0
0
0
0
10
0
0
0
0
10
10
10
% C
% Asp:
0
19
0
0
0
0
0
28
0
0
0
0
0
0
0
% D
% Glu:
28
10
0
0
19
55
10
0
28
10
0
28
46
0
10
% E
% Phe:
0
0
0
55
0
0
10
0
0
0
0
10
0
10
0
% F
% Gly:
0
28
10
0
0
0
0
0
0
10
0
0
0
0
10
% G
% His:
0
0
10
0
0
0
0
10
10
0
0
0
10
10
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
10
0
0
0
10
0
0
0
0
10
0
0
19
0
0
% K
% Leu:
0
10
0
28
0
0
55
0
0
10
0
0
10
19
19
% L
% Met:
0
0
0
10
10
0
10
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
28
10
0
0
19
19
0
0
19
19
10
46
0
28
0
% Q
% Arg:
10
10
19
0
19
0
0
0
10
0
10
10
0
28
10
% R
% Ser:
0
0
37
10
10
0
10
10
19
10
0
10
0
0
0
% S
% Thr:
0
10
10
0
10
0
0
10
10
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
10
10
0
28
10
0
0
0
28
% V
% Trp:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _