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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90B2P All Species: 29.7
Human Site: T125 Identified Species: 50.26
UniProt: Q58FF3 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q58FF3 NP_003290 399 45859 T125 R K K L V H K T L D M I K K I
Chimpanzee Pan troglodytes XP_001158554 792 91152 T468 R K K L V R K T L D M I K K I
Rhesus Macaque Macaca mulatta XP_001095189 804 92594 T468 R K K L V R K T L D M I K K I
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P08113 802 92457 T468 R K K L V R K T L D M I K K I
Rat Rattus norvegicus Q66HD0 804 92752 T468 R K K L V R K T L D M I K K I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507634 816 93562 T484 R K K L V R K T L D M I K K I
Chicken Gallus gallus P08110 795 91537 T467 R K K L V R K T L D M I K K I
Frog Xenopus laevis NP_001083114 805 92996 T467 R K K L V R K T L D M I K K I
Zebra Danio Brachydanio rerio Q90474 725 83300 L414 K N L V K K C L D L F T E L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 M406 K N L V K K T M E L I E E L T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q18688 702 80265 M392 K N L V K K C M E L I D E V A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q08277 715 81872 I407 K N L V K K C I E M F F E I A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STX5 823 94185 V498 H D D E K K D V E K S G E N D
Baker's Yeast Sacchar. cerevisiae P15108 705 80881 I397 K N I V K K L I E A F N E I A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.7 44.6 N.A. N.A. 43.5 42 N.A. 41.5 41.5 38.5 24.9 N.A. 24.8 N.A. 25.3 N.A.
Protein Similarity: 100 46.5 46.2 N.A. N.A. 45.7 44.7 N.A. 44.8 45.1 44 35.7 N.A. 37 N.A. 38.8 N.A.
P-Site Identity: 100 93.3 93.3 N.A. N.A. 93.3 93.3 N.A. 93.3 93.3 93.3 0 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 93.3 93.3 N.A. N.A. 93.3 93.3 N.A. 93.3 93.3 93.3 20 N.A. 26.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. 25.7 N.A. 22.9 25.2 N.A.
Protein Similarity: N.A. 36.3 N.A. 33 37.7 N.A.
P-Site Identity: N.A. 0 N.A. 0 0 N.A.
P-Site Similarity: N.A. 20 N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 29 % A
% Cys: 0 0 0 0 0 0 22 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 0 0 0 8 0 8 58 0 8 0 0 8 % D
% Glu: 0 0 0 8 0 0 0 0 36 0 0 8 43 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 22 8 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % G
% His: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 15 0 0 15 58 0 15 58 % I
% Lys: 36 58 58 0 43 43 58 0 0 8 0 0 58 58 0 % K
% Leu: 0 0 29 58 0 0 8 8 58 22 0 0 0 15 0 % L
% Met: 0 0 0 0 0 0 0 15 0 8 58 0 0 0 0 % M
% Asn: 0 36 0 0 0 0 0 0 0 0 0 8 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 58 0 0 0 0 50 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 8 58 0 0 0 8 0 0 8 % T
% Val: 0 0 0 36 58 0 0 8 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _