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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90AB4P All Species: 29.39
Human Site: S378 Identified Species: 58.79
UniProt: Q58FF6 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q58FF6 NP_031381 505 58264 S378 G D E M T S L S E Y V S C M K
Chimpanzee Pan troglodytes A5A6K9 733 84754 K479 G D E M V S L K D Y C T R M K
Rhesus Macaque Macaca mulatta XP_001098426 696 80269 S470 G D E M T S L S E Y V S R M K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P11499 724 83307 S470 G D E M T S L S E Y V S R M K
Rat Rattus norvegicus P34058 724 83263 S470 G D E M T S L S E Y V S R M K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518700 789 90657 S562 G D E M T S L S E Y V S R M K
Chicken Gallus gallus Q04619 725 83409 S471 G D E M T S L S E Y V S R M K
Frog Xenopus laevis NP_001086624 722 82939 T468 G D E M A S L T E Y V S R M K
Zebra Danio Brachydanio rerio O57521 725 83339 T469 G D E M T S L T E Y V S R M K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 A463 G D D F C S L A D Y V S R M K
Honey Bee Apis mellifera XP_395168 718 82735 K466 G D E V C S L K D Y V G R M K
Nematode Worm Caenorhab. elegans Q18688 702 80265 K448 G D E P T S L K E Y V S R M K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.9 59.3 N.A. N.A. 56.7 57 N.A. 50.9 54.9 53.7 52.5 N.A. 46.7 47.9 46.4 N.A.
Protein Similarity: 100 59 64.8 N.A. N.A. 62.2 62.4 N.A. 56.6 61.9 61.3 61.3 N.A. 57.1 57.5 57.2 N.A.
P-Site Identity: 100 60 93.3 N.A. N.A. 93.3 93.3 N.A. 93.3 93.3 80 86.6 N.A. 60 60 80 N.A.
P-Site Similarity: 100 73.3 93.3 N.A. N.A. 93.3 93.3 N.A. 93.3 93.3 86.6 93.3 N.A. 80 73.3 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 17 0 0 0 0 0 9 0 9 0 0 % C
% Asp: 0 100 9 0 0 0 0 0 25 0 0 0 0 0 0 % D
% Glu: 0 0 92 0 0 0 0 0 75 0 0 0 0 0 0 % E
% Phe: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 100 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 25 0 0 0 0 0 0 100 % K
% Leu: 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 75 0 0 0 0 0 0 0 0 0 100 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 92 0 0 % R
% Ser: 0 0 0 0 0 100 0 50 0 0 0 84 0 0 0 % S
% Thr: 0 0 0 0 67 0 0 17 0 0 0 9 0 0 0 % T
% Val: 0 0 0 9 9 0 0 0 0 0 92 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _