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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB3P
All Species:
45.78
Human Site:
S591
Identified Species:
83.93
UniProt:
Q58FF7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FF7
NP_031381
597
68325
S591
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
S727
L
E
G
D
D
D
T
S
R
M
E
E
V
D
_
Rhesus Macaque
Macaca mulatta
XP_001098219
597
68451
S591
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Dog
Lupus familis
XP_532154
636
72879
S630
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
S718
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Rat
Rattus norvegicus
P34058
724
83263
S718
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
D783
I
K
L
G
L
G
I
D
E
D
E
V
T
A
_
Chicken
Gallus gallus
Q04619
725
83409
S719
L
E
G
D
E
D
T
S
R
M
E
E
V
D
_
Frog
Xenopus laevis
NP_001086624
722
82939
S716
L
E
G
E
E
D
A
S
R
M
E
E
V
D
_
Zebra Danio
Brachydanio rerio
Q90474
725
83300
S719
L
E
G
D
D
D
T
S
R
M
E
E
V
D
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
S711
V
E
D
T
E
D
A
S
H
M
E
E
V
D
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
S696
E
G
A
E
E
D
A
S
R
M
E
E
V
D
_
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P55737
699
80046
S693
D
D
A
D
A
E
G
S
K
M
E
E
V
D
_
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69
95.8
83.6
N.A.
78.4
78.8
N.A.
67.5
74.7
73.5
66.3
N.A.
64
N.A.
61.9
N.A.
Protein Similarity:
100
76.2
97.8
86
N.A.
80.3
80.6
N.A.
70.3
79
78.3
75.3
N.A.
73.2
N.A.
73.5
N.A.
P-Site Identity:
100
85.7
100
100
N.A.
100
100
N.A.
7.1
92.8
92.8
85.7
N.A.
71.4
N.A.
71.4
N.A.
P-Site Similarity:
100
92.8
100
100
N.A.
100
100
N.A.
21.4
92.8
100
92.8
N.A.
78.5
N.A.
78.5
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
57
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
71.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
50
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
71.4
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
0
8
0
62
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
70
16
85
0
8
0
8
0
0
0
93
0
% D
% Glu:
8
77
0
16
70
8
0
0
8
0
100
93
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
70
8
0
8
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
70
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
93
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
77
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
24
0
0
0
0
0
8
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
8
93
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% _