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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AA5P
All Species:
1.52
Human Site:
S105
Identified Species:
2.56
UniProt:
Q58FG0
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FG0
NP_005339
334
38738
S105
A
D
K
K
K
K
K
S
K
E
K
Y
I
D
Q
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
C421
R
K
N
L
V
K
K
C
L
E
L
F
T
E
L
Rhesus Macaque
Macaca mulatta
XP_001098426
696
80269
C412
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
Dog
Lupus familis
XP_857093
509
59005
K207
K
K
K
K
K
K
I
K
E
K
Y
I
D
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
P07901
733
84769
C421
R
K
N
L
V
K
K
C
L
E
L
F
T
E
L
Rat
Rattus norvegicus
P82995
733
84796
C421
R
K
N
L
V
K
K
C
L
E
L
F
T
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512830
733
84847
C421
R
K
N
L
V
K
K
C
L
E
L
F
T
E
L
Chicken
Gallus gallus
Q04619
725
83409
C413
R
K
N
I
V
K
K
C
L
E
L
F
T
E
L
Frog
Xenopus laevis
NP_001086624
722
82939
C410
R
K
N
I
V
K
K
C
L
E
L
F
C
E
L
Zebra Danio
Brachydanio rerio
Q90474
725
83300
C413
R
K
N
L
V
K
K
C
L
D
L
F
T
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
T405
R
K
N
L
V
K
K
T
M
E
L
I
E
E
L
Honey Bee
Apis mellifera
XP_395168
718
82735
C408
R
K
N
L
V
K
K
C
I
E
L
F
E
E
L
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
K390
I
R
K
N
L
V
K
K
C
M
E
L
I
D
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P27323
700
80617
C392
R
K
N
L
V
K
K
C
I
E
M
F
N
E
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.8
32.1
49.3
N.A.
38.2
38.2
N.A.
36.9
31.3
31.2
30.7
N.A.
29.9
28.8
28.4
N.A.
Protein Similarity:
100
41.7
39.6
55.7
N.A.
41.7
41.7
N.A.
41.3
38.6
38.9
38.6
N.A.
37.5
36.9
37.1
N.A.
P-Site Identity:
100
20
20
26.6
N.A.
20
20
N.A.
20
20
20
13.3
N.A.
20
20
26.6
N.A.
P-Site Similarity:
100
33.3
33.3
46.6
N.A.
33.3
33.3
N.A.
33.3
33.3
33.3
33.3
N.A.
33.3
33.3
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
72
8
0
0
0
8
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
8
0
0
8
15
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
79
8
0
15
79
15
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
72
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
22
0
0
8
0
15
0
0
15
15
0
8
% I
% Lys:
8
86
22
15
15
93
93
15
8
8
8
0
0
0
0
% K
% Leu:
0
0
0
58
8
0
0
0
58
0
72
8
0
0
72
% L
% Met:
0
0
0
0
0
0
0
0
8
8
8
0
0
0
0
% M
% Asn:
0
0
79
8
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
79
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
43
0
0
% T
% Val:
0
0
0
0
79
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _