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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90AA5P All Species: 3.94
Human Site: T117 Identified Species: 6.67
UniProt: Q58FG0 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.77
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q58FG0 NP_005339 334 38738 T117 I D Q E L N K T K P I W T R N
Chimpanzee Pan troglodytes A5A6K9 733 84754 E433 T E L A E D K E N Y K K F Y E
Rhesus Macaque Macaca mulatta XP_001098426 696 80269 E424 S E L A E D K E N Y K K F Y E
Dog Lupus familis XP_857093 509 59005 T219 D Q E E L N K T K P I W T R N
Cat Felis silvestris
Mouse Mus musculus P07901 733 84769 E433 T E L A E D K E N Y K K F Y E
Rat Rattus norvegicus P82995 733 84796 E433 T E L A E D K E N Y K K F Y E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512830 733 84847 E433 T E L A E D K E N Y K K L Y E
Chicken Gallus gallus Q04619 725 83409 E425 T E L A E D K E N Y K K F Y E
Frog Xenopus laevis NP_001086624 722 82939 E422 C E L A E D K E N Y K K F Y E
Zebra Danio Brachydanio rerio Q90474 725 83300 D425 T E L A E D K D N Y K K Y Y E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 E417 E E L T E D K E N Y K K F Y D
Honey Bee Apis mellifera XP_395168 718 82735 D420 E E L A E D K D N Y K K F Y E
Nematode Worm Caenorhab. elegans Q18688 702 80265 K402 I D E V A E D K D N F K K F Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P27323 700 80617 E404 N E I A E N K E D Y T K F Y E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 38.8 32.1 49.3 N.A. 38.2 38.2 N.A. 36.9 31.3 31.2 30.7 N.A. 29.9 28.8 28.4 N.A.
Protein Similarity: 100 41.7 39.6 55.7 N.A. 41.7 41.7 N.A. 41.3 38.6 38.9 38.6 N.A. 37.5 36.9 37.1 N.A.
P-Site Identity: 100 6.6 6.6 80 N.A. 6.6 6.6 N.A. 6.6 6.6 6.6 6.6 N.A. 6.6 6.6 13.3 N.A.
P-Site Similarity: 100 20 20 86.6 N.A. 20 20 N.A. 20 20 20 20 N.A. 26.6 20 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 35.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 72 8 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 15 0 0 0 72 8 15 15 0 0 0 0 0 8 % D
% Glu: 15 79 15 15 79 8 0 65 0 0 0 0 0 0 72 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 65 8 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 15 0 8 0 0 0 0 0 0 0 15 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 93 8 15 0 72 86 8 0 0 % K
% Leu: 0 0 72 0 15 0 0 0 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 22 0 0 72 8 0 0 0 0 15 % N
% Pro: 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % P
% Gln: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 15 0 % R
% Ser: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 43 0 0 8 0 0 0 15 0 0 8 0 15 0 0 % T
% Val: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 79 0 0 8 79 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _