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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DCAF6
All Species:
15.76
Human Site:
S378
Identified Species:
31.52
UniProt:
Q58WW2
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58WW2
NP_001017977.1
860
96292
S378
P
R
G
G
T
S
Q
S
D
I
S
T
L
P
T
Chimpanzee
Pan troglodytes
XP_001174803
860
96251
S378
P
R
G
G
T
S
Q
S
D
I
S
T
L
P
T
Rhesus Macaque
Macaca mulatta
XP_001091583
860
96139
S378
P
R
G
G
T
S
Q
S
D
I
S
T
L
P
T
Dog
Lupus familis
XP_862582
859
95606
S378
P
R
G
G
T
S
Q
S
D
V
S
A
L
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9DC22
876
97569
Q377
R
P
R
G
G
T
N
Q
P
D
V
S
T
L
P
Rat
Rattus norvegicus
XP_213926
871
96950
P378
P
R
G
G
T
N
E
P
D
V
S
A
L
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513832
860
94531
E378
S
T
E
F
E
A
T
E
T
T
M
D
V
D
G
Chicken
Gallus gallus
XP_416649
828
92195
S369
T
M
S
A
Q
A
P
S
T
S
S
S
T
G
S
Frog
Xenopus laevis
NP_001098734
763
86014
V305
D
E
V
R
Q
P
P
V
K
R
L
R
L
R
G
Zebra Danio
Brachydanio rerio
NP_001138562
907
98726
E374
R
G
T
A
A
Q
A
E
G
T
S
S
E
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121379
813
91439
T355
T
S
L
M
Q
R
M
T
D
V
L
S
R
M
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795377
800
89350
K342
S
H
E
E
L
E
E
K
S
G
A
S
R
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
93.7
N.A.
86.1
88
N.A.
78.2
68.9
64.7
62.5
N.A.
N.A.
36.5
N.A.
26
Protein Similarity:
100
99.6
98.9
95.2
N.A.
89.2
91.1
N.A.
83.7
76.7
74.4
71.6
N.A.
N.A.
52.7
N.A.
41.4
P-Site Identity:
100
100
100
80
N.A.
6.6
66.6
N.A.
0
13.3
6.6
13.3
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
100
86.6
N.A.
20
86.6
N.A.
13.3
33.3
6.6
20
N.A.
N.A.
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
9
17
9
0
0
0
9
17
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
50
9
0
9
0
9
0
% D
% Glu:
0
9
17
9
9
9
17
17
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
42
50
9
0
0
0
9
9
0
0
0
9
25
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
25
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
9
0
0
0
0
0
17
0
50
9
9
% L
% Met:
0
9
0
9
0
0
9
0
0
0
9
0
0
9
0
% M
% Asn:
0
0
0
0
0
9
9
0
0
0
0
0
0
0
0
% N
% Pro:
42
9
0
0
0
9
17
9
9
0
0
0
0
42
9
% P
% Gln:
0
0
0
0
25
9
34
9
0
0
0
0
0
0
0
% Q
% Arg:
17
42
9
9
0
9
0
0
0
9
0
9
17
9
0
% R
% Ser:
17
9
9
0
0
34
0
42
9
9
59
42
0
0
9
% S
% Thr:
17
9
9
0
42
9
9
9
17
17
0
25
17
17
42
% T
% Val:
0
0
9
0
0
0
0
9
0
25
9
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _