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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ESCO1
All Species:
18.48
Human Site:
T434
Identified Species:
50.83
UniProt:
Q5FWF5
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5FWF5
NP_443143.2
840
94983
T434
L
E
M
H
H
P
V
T
Q
S
T
F
L
G
T
Chimpanzee
Pan troglodytes
XP_523883
839
94987
T433
L
E
M
H
H
P
V
T
Q
S
T
F
L
R
T
Rhesus Macaque
Macaca mulatta
XP_001091733
840
94911
T434
L
E
M
H
H
P
M
T
Q
S
T
F
L
G
T
Dog
Lupus familis
XP_547645
900
101219
T492
L
E
M
H
H
P
A
T
Q
S
T
F
L
G
T
Cat
Felis silvestris
Mouse
Mus musculus
Q69Z69
843
94980
S437
L
E
M
P
H
P
V
S
Q
S
T
F
L
E
M
Rat
Rattus norvegicus
NP_001119771
319
36659
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507407
288
32617
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5SPR8
609
68341
K223
Y
E
K
P
S
I
R
K
P
V
R
E
K
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791750
838
93461
T443
I
D
D
D
M
E
E
T
E
N
L
L
K
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
96.3
81.3
N.A.
75.9
35.5
N.A.
30.9
N.A.
N.A.
31.5
N.A.
N.A.
N.A.
N.A.
25.1
Protein Similarity:
100
99.4
98.2
86
N.A.
85.4
37.3
N.A.
32.9
N.A.
N.A.
47.7
N.A.
N.A.
N.A.
N.A.
43.8
P-Site Identity:
100
93.3
93.3
93.3
N.A.
73.3
0
N.A.
0
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
100
93.3
N.A.
80
0
N.A.
0
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
12
12
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
67
0
0
0
12
12
0
12
0
0
12
0
23
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
56
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
34
0
% G
% His:
0
0
0
45
56
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
12
0
0
0
0
12
0
0
0
0
23
0
0
% K
% Leu:
56
0
0
0
0
0
0
0
0
0
12
12
56
0
12
% L
% Met:
0
0
56
0
12
0
12
0
0
0
0
0
0
0
12
% M
% Asn:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% N
% Pro:
0
0
0
23
0
56
0
0
12
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
56
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
12
0
0
0
12
0
0
23
0
% R
% Ser:
0
0
0
0
12
0
0
12
0
56
0
0
0
0
12
% S
% Thr:
0
0
0
0
0
0
0
56
0
0
56
0
0
0
45
% T
% Val:
0
0
0
0
0
0
34
0
0
12
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _