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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FIGN All Species: 10
Human Site: S418 Identified Species: 14.67
UniProt: Q5HY92 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5HY92 NP_060556.2 759 82146 S418 L G S R S S E S F G K Y T S P
Chimpanzee Pan troglodytes XP_001153855 674 74011 K359 Q N G G M Q C K P Y G A G P T
Rhesus Macaque Macaca mulatta XP_001097992 759 82110 S418 L G S R S S E S F G K Y T S P
Dog Lupus familis XP_545496 695 74019 G380 L L P H G L Q G P A L R A P T
Cat Felis silvestris
Mouse Mus musculus Q9ERZ6 759 82080 S418 L G S R S S E S F G K Y T S P
Rat Rattus norvegicus Q6GX84 677 74178 K362 Q N G N V K P K S S R A G S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506217 731 78137 C415 V A N G G A R C G P R A A A P
Chicken Gallus gallus Q5ZK92 613 66247 P298 K N S R T N K P S T P T P A A
Frog Xenopus laevis Q6DDU8 655 72133 R339 E D V E D S N R K V Y G Q G N
Zebra Danio Brachydanio rerio Q503S1 736 79183 G414 S P V M S D H G D D S R Q H L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQN8 523 58530 A208 S N F V S P V A Q N D N S T S
Honey Bee Apis mellifera XP_625184 585 66969 E270 Q E N M Y N N E I D T M E V E
Nematode Worm Caenorhab. elegans O16299 594 66169 D279 D T E G G G K D E K M S G L R
Sea Urchin Strong. purpuratus XP_783737 603 65189 S288 G S G G Q S G S M S N N N N Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 K208 N G D A E D G K S K R G L Y E
Baker's Yeast Sacchar. cerevisiae P39955 897 100313 Q509 P Y S H G A S Q N K K P S K N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.6 99.4 72.9 N.A. 97.8 35.5 N.A. 31.6 24.8 35.7 71.2 N.A. 25.2 26.6 26.4 30.8
Protein Similarity: 100 54.9 99.4 79.1 N.A. 99.3 54.9 N.A. 47 42.2 53.4 83.7 N.A. 40.8 46.6 43.3 46.9
P-Site Identity: 100 0 100 6.6 N.A. 100 6.6 N.A. 6.6 13.3 6.6 6.6 N.A. 6.6 0 0 13.3
P-Site Similarity: 100 0 100 13.3 N.A. 100 13.3 N.A. 40 40 6.6 6.6 N.A. 26.6 13.3 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. 23.9 25 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 0 13 0 7 0 7 0 19 13 13 13 % A
% Cys: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % C
% Asp: 7 7 7 0 7 13 0 7 7 13 7 0 0 0 0 % D
% Glu: 7 7 7 7 7 0 19 7 7 0 0 0 7 0 13 % E
% Phe: 0 0 7 0 0 0 0 0 19 0 0 0 0 0 0 % F
% Gly: 7 25 19 25 25 7 13 13 7 19 7 13 19 7 0 % G
% His: 0 0 0 13 0 0 7 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % I
% Lys: 7 0 0 0 0 7 13 19 7 19 25 0 0 7 0 % K
% Leu: 25 7 0 0 0 7 0 0 0 0 7 0 7 7 7 % L
% Met: 0 0 0 13 7 0 0 0 7 0 7 7 0 0 0 % M
% Asn: 7 25 13 7 0 13 13 0 7 7 7 13 7 7 13 % N
% Pro: 7 7 7 0 0 7 7 7 13 7 7 7 7 13 25 % P
% Gln: 19 0 0 0 7 7 7 7 7 0 0 0 13 0 7 % Q
% Arg: 0 0 0 25 0 0 7 7 0 0 19 13 0 0 7 % R
% Ser: 13 7 32 0 32 32 7 25 19 13 7 7 13 25 7 % S
% Thr: 0 7 0 0 7 0 0 0 0 7 7 7 19 7 13 % T
% Val: 7 0 13 7 7 0 7 0 0 7 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 7 0 0 0 0 7 7 19 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _