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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FIGN All Species: 11.82
Human Site: S424 Identified Species: 17.33
UniProt: Q5HY92 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5HY92 NP_060556.2 759 82146 S424 E S F G K Y T S P V M S E H G
Chimpanzee Pan troglodytes XP_001153855 674 74011 P365 C K P Y G A G P T E P A H P V
Rhesus Macaque Macaca mulatta XP_001097992 759 82110 S424 E S F G K Y T S P V M S E H G
Dog Lupus familis XP_545496 695 74019 P386 Q G P A L R A P T S A G H A A
Cat Felis silvestris
Mouse Mus musculus Q9ERZ6 759 82080 S424 E S F G K Y T S P V M S E H G
Rat Rattus norvegicus Q6GX84 677 74178 S368 P K S S R A G S A E P A H L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506217 731 78137 A421 R C G P R A A A P A E P A P P
Chicken Gallus gallus Q5ZK92 613 66247 A304 K P S T P T P A A R K K K D T
Frog Xenopus laevis Q6DDU8 655 72133 G345 N R K V Y G Q G N S E M N S T
Zebra Danio Brachydanio rerio Q503S1 736 79183 H420 H G D D S R Q H L P H S I D T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQN8 523 58530 T214 V A Q N D N S T S S R S S S I
Honey Bee Apis mellifera XP_625184 585 66969 V276 N E I D T M E V E D E R L K N
Nematode Worm Caenorhab. elegans O16299 594 66169 L285 K D E K M S G L R A E P T L K
Sea Urchin Strong. purpuratus XP_783737 603 65189 N294 G S M S N N N N Q E E P T D E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 Y214 G K S K R G L Y E G P D E D L
Baker's Yeast Sacchar. cerevisiae P39955 897 100313 K515 S Q N K K P S K N Q T T S M S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.6 99.4 72.9 N.A. 97.8 35.5 N.A. 31.6 24.8 35.7 71.2 N.A. 25.2 26.6 26.4 30.8
Protein Similarity: 100 54.9 99.4 79.1 N.A. 99.3 54.9 N.A. 47 42.2 53.4 83.7 N.A. 40.8 46.6 43.3 46.9
P-Site Identity: 100 0 100 0 N.A. 100 6.6 N.A. 6.6 0 0 6.6 N.A. 6.6 0 0 6.6
P-Site Similarity: 100 6.6 100 6.6 N.A. 100 20 N.A. 20 20 0 6.6 N.A. 26.6 0 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 23.9 25 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.5 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 0 19 13 13 13 13 7 13 7 7 7 % A
% Cys: 7 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 7 13 7 0 0 0 0 7 0 7 0 25 0 % D
% Glu: 19 7 7 0 0 0 7 0 13 19 32 0 25 0 7 % E
% Phe: 0 0 19 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 13 13 7 19 7 13 19 7 0 7 0 7 0 0 19 % G
% His: 7 0 0 0 0 0 0 7 0 0 7 0 19 19 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 0 0 7 0 7 % I
% Lys: 13 19 7 19 25 0 0 7 0 0 7 7 7 7 7 % K
% Leu: 0 0 0 0 7 0 7 7 7 0 0 0 7 13 7 % L
% Met: 0 0 7 0 7 7 0 0 0 0 19 7 0 7 0 % M
% Asn: 13 0 7 7 7 13 7 7 13 0 0 0 7 0 7 % N
% Pro: 7 7 13 7 7 7 7 13 25 7 19 19 0 13 7 % P
% Gln: 7 7 7 0 0 0 13 0 7 7 0 0 0 0 0 % Q
% Arg: 7 7 0 0 19 13 0 0 7 7 7 7 0 0 0 % R
% Ser: 7 25 19 13 7 7 13 25 7 19 0 32 13 13 7 % S
% Thr: 0 0 0 7 7 7 19 7 13 0 7 7 13 0 25 % T
% Val: 7 0 0 7 0 0 0 7 0 19 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 7 19 0 7 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _