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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EFHC2 All Species: 16.36
Human Site: S665 Identified Species: 40
UniProt: Q5JST6 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5JST6 NP_079460.2 749 87397 S665 D I K R L C K S S R L P L S D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001097580 735 86010 S651 D I K R L C K S S R L P L S D
Dog Lupus familis XP_538007 779 90137 S695 D I R R L C K S F R L P L S D
Cat Felis silvestris
Mouse Mus musculus Q9D485 750 87628 S664 D I R R M C K S S R L P L D D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512633 814 92626 A729 E I R T I C K A F R L P L A D
Chicken Gallus gallus Q32TG3 746 86643 S664 T C R T I C K S F K L P L S D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q32TF8 748 85439 A662 E A R I I C K A F R L P L S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611459 765 88083 G679 Q V R S T L R G C R L P F S L
Honey Bee Apis mellifera XP_396096 750 88874 G657 R V Y I T L R G C K I P I D L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_798540 744 85632 A662 L V R S T C N A F H L P L P D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.8 74.3 N.A. 74.1 N.A. N.A. 55.2 56.4 N.A. 53 N.A. 33.4 35.3 N.A. 47.1
Protein Similarity: 100 N.A. 95.4 83.6 N.A. 85.5 N.A. N.A. 70.8 73.6 N.A. 70.4 N.A. 54.2 58.1 N.A. 65.1
P-Site Identity: 100 N.A. 100 86.6 N.A. 80 N.A. N.A. 53.3 53.3 N.A. 53.3 N.A. 26.6 6.6 N.A. 33.3
P-Site Similarity: 100 N.A. 100 93.3 N.A. 93.3 N.A. N.A. 86.6 73.3 N.A. 80 N.A. 46.6 40 N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 0 0 30 0 0 0 0 0 10 0 % A
% Cys: 0 10 0 0 0 80 0 0 20 0 0 0 0 0 0 % C
% Asp: 40 0 0 0 0 0 0 0 0 0 0 0 0 20 80 % D
% Glu: 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 50 0 0 0 10 0 0 % F
% Gly: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 50 0 20 30 0 0 0 0 0 10 0 10 0 0 % I
% Lys: 0 0 20 0 0 0 70 0 0 20 0 0 0 0 0 % K
% Leu: 10 0 0 0 30 20 0 0 0 0 90 0 80 0 20 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 100 0 10 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 70 40 0 0 20 0 0 70 0 0 0 0 0 % R
% Ser: 0 0 0 20 0 0 0 50 30 0 0 0 0 60 0 % S
% Thr: 10 0 0 20 30 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 30 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _