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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
17.88
Human Site:
S226
Identified Species:
30.26
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
S226
K
L
I
P
R
H
Q
S
I
F
K
S
N
G
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
S226
K
L
I
P
R
H
Q
S
I
F
K
S
N
R
F
Dog
Lupus familis
XP_851459
362
41706
S246
K
L
I
P
R
H
Q
S
I
F
K
S
N
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
S226
K
L
I
P
R
H
Q
S
I
F
R
S
N
Q
F
Rat
Rattus norvegicus
Q66HE7
352
40881
Q227
D
L
I
P
R
H
Q
Q
V
F
S
M
N
Q
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
Q227
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
F
Chicken
Gallus gallus
P13863
303
34670
P229
T
P
N
N
D
V
W
P
D
V
E
S
L
Q
D
Frog
Xenopus laevis
P23437
297
33852
P228
T
P
D
E
V
S
W
P
G
V
T
T
M
P
D
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
Q227
E
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
Q335
D
L
L
P
R
H
I
Q
I
F
G
Q
N
E
Y
Honey Bee
Apis mellifera
XP_394980
385
44993
A250
D
L
L
P
R
H
L
A
I
F
Q
Q
N
E
F
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
S226
E
F
L
P
R
H
I
S
I
F
R
T
N
Q
F
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
H227
K
L
E
F
R
S
K
H
S
K
I
F
S
T
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
T222
K
I
F
R
I
L
G
T
P
N
E
Q
S
W
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
86.6
53.3
N.A.
60
6.6
0
60
N.A.
46.6
53.3
53.3
20
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
93.3
66.6
N.A.
73.3
13.3
6.6
80
N.A.
60
73.3
80
33.3
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
29
0
8
0
8
0
0
0
8
0
0
0
0
0
15
% D
% Glu:
15
0
8
8
0
0
0
0
0
0
15
0
0
15
0
% E
% Phe:
0
8
8
8
0
0
0
0
0
72
0
8
0
0
58
% F
% Gly:
0
0
0
0
0
0
8
0
8
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
72
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
50
0
8
0
15
0
50
0
8
0
0
0
0
% I
% Lys:
43
0
0
0
0
0
8
0
0
8
22
0
0
0
0
% K
% Leu:
0
72
22
0
0
8
8
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% M
% Asn:
0
0
8
8
0
0
0
0
0
8
0
0
72
0
8
% N
% Pro:
0
15
0
72
0
0
0
15
8
0
0
0
0
8
8
% P
% Gln:
0
0
0
0
0
0
50
29
0
0
8
22
0
50
0
% Q
% Arg:
0
0
0
8
79
0
0
0
0
0
15
0
0
8
0
% R
% Ser:
0
0
0
0
0
15
0
36
8
0
22
36
15
0
0
% S
% Thr:
15
0
0
0
0
0
0
8
0
0
8
29
0
8
0
% T
% Val:
0
0
0
0
8
8
0
0
22
15
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
15
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _