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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
12.73
Human Site:
S253
Identified Species:
21.54
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
S253
E
T
L
E
E
K
F
S
D
V
H
P
V
A
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
S253
E
T
L
E
E
K
F
S
D
A
H
P
V
A
L
Dog
Lupus familis
XP_851459
362
41706
S273
E
T
L
E
E
K
F
S
D
A
H
P
M
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
S253
E
T
L
E
E
K
F
S
N
V
Q
P
V
A
L
Rat
Rattus norvegicus
Q66HE7
352
40881
P254
E
T
L
E
L
K
F
P
N
I
S
Y
S
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
P254
E
P
L
E
S
K
F
P
N
I
S
S
P
A
L
Chicken
Gallus gallus
P13863
303
34670
L256
L
G
T
H
V
Q
N
L
D
E
D
G
L
D
L
Frog
Xenopus laevis
P23437
297
33852
L255
F
S
K
V
V
P
P
L
D
E
D
G
R
D
L
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
P254
E
P
L
E
L
K
Y
P
N
L
S
Y
Q
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
P362
E
P
L
E
D
K
M
P
A
K
S
Q
Q
N
P
Honey Bee
Apis mellifera
XP_394980
385
44993
P277
I
P
L
E
I
V
L
P
K
R
G
N
T
I
L
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
P253
E
P
L
P
S
K
L
P
N
A
S
S
A
Q
L
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
K254
R
R
I
P
L
K
D
K
V
R
N
L
N
S
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
L249
P
R
W
Q
A
Q
D
L
A
T
V
V
P
N
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
93.3
80
N.A.
86.6
53.3
N.A.
46.6
13.3
13.3
40
N.A.
26.6
20
26.6
6.6
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
93.3
66.6
N.A.
60
26.6
20
60
N.A.
33.3
20
33.3
26.6
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
15
22
0
0
8
43
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
15
0
36
0
15
0
0
15
0
% D
% Glu:
65
0
0
65
29
0
0
0
0
15
0
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
43
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
8
15
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
22
0
0
0
0
% H
% Ile:
8
0
8
0
8
0
0
0
0
15
0
0
0
8
0
% I
% Lys:
0
0
8
0
0
72
0
8
8
8
0
0
0
0
0
% K
% Leu:
8
0
72
0
22
0
15
22
0
8
0
8
8
0
86
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
36
0
8
8
8
15
0
% N
% Pro:
8
36
0
15
0
8
8
43
0
0
0
29
15
0
8
% P
% Gln:
0
0
0
8
0
15
0
0
0
0
8
8
15
8
0
% Q
% Arg:
8
15
0
0
0
0
0
0
0
15
0
0
8
0
0
% R
% Ser:
0
8
0
0
15
0
0
29
0
0
36
15
8
15
0
% S
% Thr:
0
36
8
0
0
0
0
0
0
8
0
0
8
0
8
% T
% Val:
0
0
0
8
15
8
0
0
8
15
8
8
22
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _