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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
18.18
Human Site:
T247
Identified Species:
30.77
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
T247
P
E
P
E
D
M
E
T
L
E
E
K
F
S
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
T247
P
E
P
E
D
M
E
T
L
E
E
K
F
S
D
Dog
Lupus familis
XP_851459
362
41706
T267
P
E
P
E
D
M
E
T
L
E
E
K
F
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
T247
P
E
P
E
D
M
E
T
L
E
E
K
F
S
N
Rat
Rattus norvegicus
Q66HE7
352
40881
T248
P
D
P
E
D
M
E
T
L
E
L
K
F
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
P248
P
D
P
E
N
T
E
P
L
E
S
K
F
P
N
Chicken
Gallus gallus
P13863
303
34670
G250
K
W
K
P
G
S
L
G
T
H
V
Q
N
L
D
Frog
Xenopus laevis
P23437
297
33852
S249
K
W
I
R
Q
D
F
S
K
V
V
P
P
L
D
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
P248
P
E
P
Q
E
M
E
P
L
E
L
K
Y
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
P356
P
V
P
P
T
L
E
P
L
E
D
K
M
P
A
Honey Bee
Apis mellifera
XP_394980
385
44993
P271
P
T
P
Q
T
L
I
P
L
E
I
V
L
P
K
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
P247
P
E
P
E
H
L
E
P
L
P
S
K
L
P
N
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
R248
S
I
P
E
P
E
R
R
I
P
L
K
D
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
R243
D
F
K
T
A
F
P
R
W
Q
A
Q
D
L
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
73.3
N.A.
53.3
6.6
6.6
53.3
N.A.
40
26.6
46.6
20
P-Site Similarity:
100
N.A.
100
100
N.A.
100
86.6
N.A.
73.3
13.3
13.3
80
N.A.
53.3
40
60
26.6
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
15
0
0
36
8
0
0
0
0
8
0
15
0
36
% D
% Glu:
0
43
0
58
8
8
65
0
0
65
29
0
0
0
0
% E
% Phe:
0
8
0
0
0
8
8
0
0
0
0
0
43
0
0
% F
% Gly:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
8
0
8
0
8
0
0
0
0
% I
% Lys:
15
0
15
0
0
0
0
0
8
0
0
72
0
8
8
% K
% Leu:
0
0
0
0
0
22
8
0
72
0
22
0
15
22
0
% L
% Met:
0
0
0
0
0
43
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
36
% N
% Pro:
72
0
79
15
8
0
8
36
0
15
0
8
8
43
0
% P
% Gln:
0
0
0
15
8
0
0
0
0
8
0
15
0
0
0
% Q
% Arg:
0
0
0
8
0
0
8
15
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
8
0
8
0
0
15
0
0
29
0
% S
% Thr:
0
8
0
8
15
8
0
36
8
0
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
8
15
8
0
0
8
% V
% Trp:
0
15
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _