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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
39.7
Human Site:
T276
Identified Species:
67.18
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
T276
M
N
P
D
D
R
L
T
C
S
Q
L
L
E
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
T276
M
N
P
D
D
R
S
T
C
S
Q
L
L
E
S
Dog
Lupus familis
XP_851459
362
41706
T296
M
N
P
D
D
R
L
T
C
A
Q
L
L
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
T276
M
N
P
D
E
R
L
T
C
A
Q
L
L
D
S
Rat
Rattus norvegicus
Q66HE7
352
40881
T277
M
D
P
A
E
R
L
T
C
E
Q
L
L
Q
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
T277
M
D
P
A
A
R
L
T
C
E
Q
L
L
Q
L
Chicken
Gallus gallus
P13863
303
34670
S277
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
Frog
Xenopus laevis
P23437
297
33852
D270
L
A
Q
M
L
Q
Y
D
S
N
K
R
I
S
A
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
S277
M
D
P
A
E
R
L
S
C
E
Q
L
L
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
S388
K
D
P
T
K
R
W
S
C
E
K
L
T
K
H
Honey Bee
Apis mellifera
XP_394980
385
44993
S302
K
D
P
D
E
R
W
S
C
E
Q
L
L
Q
H
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
S276
M
S
P
D
R
R
F
S
C
S
E
L
M
L
H
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
S279
M
D
P
A
D
R
L
S
C
Q
E
L
M
E
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
S265
P
A
G
L
D
L
L
S
K
M
L
R
Y
E
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
80
60
N.A.
60
20
0
60
N.A.
26.6
46.6
46.6
53.3
P-Site Similarity:
100
N.A.
93.3
100
N.A.
100
80
N.A.
73.3
40
40
80
N.A.
53.3
73.3
73.3
80
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
36
8
0
0
0
0
15
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
79
0
0
0
0
0
0
% C
% Asp:
0
50
0
43
36
0
0
8
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
29
0
0
0
0
36
15
0
0
43
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
36
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% I
% Lys:
15
0
0
0
15
0
0
0
8
8
15
0
0
8
0
% K
% Leu:
8
0
0
8
8
8
58
0
0
0
8
79
65
8
8
% L
% Met:
65
0
0
8
0
0
0
0
0
8
8
0
15
0
8
% M
% Asn:
0
29
0
0
0
0
0
0
0
8
0
0
0
8
0
% N
% Pro:
8
0
86
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
8
0
0
8
0
0
0
8
58
0
0
22
8
% Q
% Arg:
0
0
0
0
8
86
0
0
0
0
0
15
0
0
0
% R
% Ser:
0
8
0
0
0
0
8
50
8
22
0
0
0
8
29
% S
% Thr:
0
0
0
8
0
0
0
43
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _