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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
43.64
Human Site:
T86
Identified Species:
73.85
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
T86
V
F
E
Y
C
D
H
T
L
L
N
E
L
E
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
T86
V
F
E
Y
C
D
H
T
L
L
N
E
L
E
R
Dog
Lupus familis
XP_851459
362
41706
T86
V
F
E
Y
C
D
H
T
L
L
N
E
L
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
T86
V
F
E
Y
C
D
H
T
L
L
N
E
L
E
R
Rat
Rattus norvegicus
Q66HE7
352
40881
T86
V
F
E
Y
C
H
H
T
V
L
H
E
L
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
T86
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
Chicken
Gallus gallus
P13863
303
34670
D86
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
T
Frog
Xenopus laevis
P23437
297
33852
D86
V
F
E
F
L
N
Q
D
L
K
K
F
M
D
G
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
T86
V
F
E
Y
C
D
H
T
V
L
N
E
L
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
T195
V
F
E
F
C
E
L
T
V
L
H
E
L
E
R
Honey Bee
Apis mellifera
XP_394980
385
44993
T110
V
F
E
Y
C
E
Y
T
L
L
N
E
M
E
R
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
T86
V
F
E
L
C
D
R
T
V
L
H
E
L
E
K
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
T86
V
F
E
Y
C
D
Y
T
V
L
N
T
L
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
D86
V
F
E
Y
L
D
L
D
L
K
K
F
M
D
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
100
100
N.A.
100
73.3
N.A.
80
26.6
26.6
86.6
N.A.
66.6
80
66.6
73.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
93.3
N.A.
100
46.6
53.3
100
N.A.
93.3
100
86.6
86.6
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
79
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
65
0
22
0
0
0
0
0
43
0
% D
% Glu:
0
0
100
0
0
15
0
0
0
0
0
72
0
58
0
% E
% Phe:
0
100
0
22
0
0
0
0
0
0
0
15
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
8
50
0
0
0
29
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
22
22
0
0
0
8
% K
% Leu:
0
0
0
8
22
0
15
0
58
79
0
0
79
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
22
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
50
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
65
% R
% Ser:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
79
0
0
0
8
0
0
8
% T
% Val:
93
0
0
0
0
0
0
0
43
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
72
0
0
15
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _