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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMEK2
All Species:
44.24
Human Site:
T427
Identified Species:
88.48
UniProt:
Q5MIZ7
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MIZ7
NP_001116436.1
849
97444
T427
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Chimpanzee
Pan troglodytes
XP_001140788
1051
117499
T656
I
E
H
M
I
C
D
T
D
P
E
L
G
G
A
Rhesus Macaque
Macaca mulatta
XP_001112386
1020
115840
T598
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Dog
Lupus familis
XP_531833
1069
121076
T676
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q922R5
820
93916
T427
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Rat
Rattus norvegicus
NP_001101837
820
93952
T427
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510357
821
93689
T428
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Chicken
Gallus gallus
XP_424305
819
93429
T426
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Frog
Xenopus laevis
Q7ZX60
820
93708
S427
I
E
Q
M
I
C
D
S
D
P
E
L
G
G
A
Zebra Danio
Brachydanio rerio
Q5SP90
818
93771
T425
I
E
H
M
I
C
D
T
D
P
E
L
G
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFS5
980
109277
S429
I
E
Q
M
L
N
D
S
E
P
E
L
G
I
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40164
858
98034
D451
Q
H
K
S
A
P
D
D
K
S
S
H
R
K
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.2
82.6
75.4
N.A.
93
94.1
N.A.
89.2
91
89.5
70.9
N.A.
41.6
N.A.
N.A.
N.A.
Protein Similarity:
100
67.5
82.8
75.7
N.A.
94.5
95
N.A.
91.1
92.5
93
83.3
N.A.
59.3
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
66.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
86.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
92
% A
% Cys:
0
0
0
0
0
84
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
100
9
84
0
0
0
0
0
0
% D
% Glu:
0
92
0
0
0
0
0
0
9
0
92
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
92
84
0
% G
% His:
0
9
17
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
92
0
0
0
84
0
0
0
0
0
0
0
0
9
0
% I
% Lys:
0
0
9
0
0
0
0
0
9
0
0
0
0
9
0
% K
% Leu:
0
0
0
0
9
0
0
0
0
0
0
92
0
0
0
% L
% Met:
0
0
0
92
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
0
92
0
0
0
0
0
% P
% Gln:
9
0
75
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% R
% Ser:
0
0
0
9
0
0
0
17
0
9
9
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
75
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _