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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPDYC All Species: 14.85
Human Site: S217 Identified Species: 36.3
UniProt: Q5MJ68 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5MJ68 NP_001008778.1 293 33166 S217 G L S P P H C S P C G L P Q H
Chimpanzee Pan troglodytes XP_508546 355 39592 S279 G L S P P H C S P C G L P Q H
Rhesus Macaque Macaca mulatta XP_001118180 538 59269 S462 G L S P P H C S P C G L P Q H
Dog Lupus familis XP_533235 197 22566 W136 L W A L G K D W R C R V A D F
Cat Felis silvestris
Mouse Mus musculus Q5IBH7 310 36038 S228 S A T P V D C S L C G K K G R
Rat Rattus norvegicus Q8R496 312 36205 S228 S A T P V D C S L C G K K G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509302 311 36120 S228 N A T P E D C S L C G K K R C
Chicken Gallus gallus
Frog Xenopus laevis Q9YGL1 298 34536 F211 L R N E D D F F P R G P G L T
Zebra Danio Brachydanio rerio NP_001006091 289 33220 F220 A A S P E P C F L C A K T S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782631 266 30955 E203 P D Y D D D N E A I P M G P D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.4 53.3 43.6 N.A. 33.8 34.9 N.A. 36 N.A. 41.6 34.8 N.A. N.A. N.A. N.A. 32.4
Protein Similarity: 100 81.9 53.3 48.8 N.A. 46.4 48.4 N.A. 47.2 N.A. 52.3 50.1 N.A. N.A. N.A. N.A. 46
P-Site Identity: 100 100 100 6.6 N.A. 33.3 33.3 N.A. 33.3 N.A. 13.3 26.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 20 N.A. 40 40 N.A. 46.6 N.A. 20 26.6 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 40 10 0 0 0 0 0 10 0 10 0 10 0 10 % A
% Cys: 0 0 0 0 0 0 70 0 0 80 0 0 0 0 10 % C
% Asp: 0 10 0 10 20 50 10 0 0 0 0 0 0 10 10 % D
% Glu: 0 0 0 10 20 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 10 20 0 0 0 0 0 0 10 % F
% Gly: 30 0 0 0 10 0 0 0 0 0 70 0 20 20 0 % G
% His: 0 0 0 0 0 30 0 0 0 0 0 0 0 0 30 % H
% Ile: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 10 0 0 0 0 0 40 30 0 0 % K
% Leu: 20 30 0 10 0 0 0 0 40 0 0 30 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 10 0 10 0 0 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 0 70 30 10 0 0 40 0 10 10 30 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 30 0 % Q
% Arg: 0 10 0 0 0 0 0 0 10 10 10 0 0 10 20 % R
% Ser: 20 0 40 0 0 0 0 60 0 0 0 0 0 10 0 % S
% Thr: 0 0 30 0 0 0 0 0 0 0 0 0 10 0 10 % T
% Val: 0 0 0 0 20 0 0 0 0 0 0 10 0 0 0 % V
% Trp: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _