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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPDYA All Species: 13.94
Human Site: S244 Identified Species: 34.07
UniProt: Q5MJ70 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5MJ70 NP_001008779.1 313 36463 S244 Y V R L G L S S S S S L S S H
Chimpanzee Pan troglodytes XP_515374 225 26070 S157 V R L G L S S S S S L S S H T
Rhesus Macaque Macaca mulatta XP_001102674 313 36653 S244 Y V R L G L S S S S S L S S H
Dog Lupus familis XP_533235 197 22566 L129 D P K C V I F L W A L G K D W
Cat Felis silvestris
Mouse Mus musculus Q5IBH7 310 36038 L241 G R Y V R L G L S S S S S S S
Rat Rattus norvegicus Q8R496 312 36205 S243 Y V R L G L S S S S S S S S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509302 311 36120 S243 V E L G L S S S S Q S S S S L
Chicken Gallus gallus
Frog Xenopus laevis Q9PU13 299 34670 S221 G P G L T P A S C T L C H K A
Zebra Danio Brachydanio rerio NP_001006091 289 33220 C219 P A A S P E P C F L C A K T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782631 266 30955 Y198 A V R K Y P D Y D D D N E A I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71.8 97.4 28.4 N.A. 83.3 85.9 N.A. 69.3 N.A. 39.6 49.8 N.A. N.A. N.A. N.A. 42.8
Protein Similarity: 100 71.8 98.7 38.6 N.A. 90 91 N.A. 80.8 N.A. 55.9 64.8 N.A. N.A. N.A. N.A. 59.4
P-Site Identity: 100 33.3 100 0 N.A. 40 86.6 N.A. 40 N.A. 13.3 0 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 33.3 100 20 N.A. 46.6 86.6 N.A. 40 N.A. 26.6 6.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 10 0 0 0 10 0 0 10 0 10 0 10 10 % A
% Cys: 0 0 0 10 0 0 0 10 10 0 10 10 0 0 0 % C
% Asp: 10 0 0 0 0 0 10 0 10 10 10 0 0 10 10 % D
% Glu: 0 10 0 0 0 10 0 0 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 10 0 10 0 0 0 0 0 0 % F
% Gly: 20 0 10 20 30 0 10 0 0 0 0 10 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 10 20 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % I
% Lys: 0 0 10 10 0 0 0 0 0 0 0 0 20 10 0 % K
% Leu: 0 0 20 40 20 40 0 20 0 10 30 20 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % N
% Pro: 10 20 0 0 10 20 10 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Q
% Arg: 0 20 40 0 10 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 20 50 60 60 50 50 40 60 50 20 % S
% Thr: 0 0 0 0 10 0 0 0 0 10 0 0 0 10 10 % T
% Val: 20 40 0 10 10 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % W
% Tyr: 30 0 10 0 10 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _