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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPDYA All Species: 7.88
Human Site: Y279 Identified Species: 19.26
UniProt: Q5MJ70 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5MJ70 NP_001008779.1 313 36463 Y279 I G D P S Q A Y T G S E V V N
Chimpanzee Pan troglodytes XP_515374 225 26070 T192 G D P S Q A Y T G S E V V N D
Rhesus Macaque Macaca mulatta XP_001102674 313 36653 Y279 I D D P S Q A Y T S S Q V V N
Dog Lupus familis XP_533235 197 22566 C164 R A M V S R Q C C E E V M A K
Cat Felis silvestris
Mouse Mus musculus Q5IBH7 310 36038 H276 D T A G D P P H T Y S Q V A N
Rat Rattus norvegicus Q8R496 312 36205 N278 I G D P S Q A N T Y S Q V A N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509302 311 36120 Y278 L Y E P S Q F Y C S Q V P Y E
Chicken Gallus gallus
Frog Xenopus laevis Q9PU13 299 34670 W256 F H Y T N R E W S Q E L L M L
Zebra Danio Brachydanio rerio NP_001006091 289 33220 S254 R K A S H R A S K T T K A Q H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782631 266 30955 L233 I L N S T S S L Q N H T F L T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 71.8 97.4 28.4 N.A. 83.3 85.9 N.A. 69.3 N.A. 39.6 49.8 N.A. N.A. N.A. N.A. 42.8
Protein Similarity: 100 71.8 98.7 38.6 N.A. 90 91 N.A. 80.8 N.A. 55.9 64.8 N.A. N.A. N.A. N.A. 59.4
P-Site Identity: 100 6.6 80 6.6 N.A. 26.6 73.3 N.A. 26.6 N.A. 0 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 13.3 86.6 20 N.A. 40 80 N.A. 40 N.A. 40 33.3 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 20 0 0 10 40 0 0 0 0 0 10 30 0 % A
% Cys: 0 0 0 0 0 0 0 10 20 0 0 0 0 0 0 % C
% Asp: 10 20 30 0 10 0 0 0 0 0 0 0 0 0 10 % D
% Glu: 0 0 10 0 0 0 10 0 0 10 30 10 0 0 10 % E
% Phe: 10 0 0 0 0 0 10 0 0 0 0 0 10 0 0 % F
% Gly: 10 20 0 10 0 0 0 0 10 10 0 0 0 0 0 % G
% His: 0 10 0 0 10 0 0 10 0 0 10 0 0 0 10 % H
% Ile: 40 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 0 0 0 0 0 0 10 0 0 10 0 0 10 % K
% Leu: 10 10 0 0 0 0 0 10 0 0 0 10 10 10 10 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 10 10 0 % M
% Asn: 0 0 10 0 10 0 0 10 0 10 0 0 0 10 40 % N
% Pro: 0 0 10 40 0 10 10 0 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 10 40 10 0 10 10 10 30 0 10 0 % Q
% Arg: 20 0 0 0 0 30 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 30 50 10 10 10 10 30 40 0 0 0 0 % S
% Thr: 0 10 0 10 10 0 0 10 40 10 10 10 0 0 10 % T
% Val: 0 0 0 10 0 0 0 0 0 0 0 30 50 20 0 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 10 10 0 0 0 10 30 0 20 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _