KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC6
All Species:
6.06
Human Site:
S258
Identified Species:
11.11
UniProt:
Q5RKV6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5RKV6
NP_478126.1
272
28235
S258
L
Y
P
V
L
Q
Q
S
L
V
R
A
A
R
R
Chimpanzee
Pan troglodytes
XP_523406
272
28247
S258
L
Y
P
V
L
Q
Q
S
L
V
R
A
A
R
R
Rhesus Macaque
Macaca mulatta
XP_001101736
185
19058
R178
S
L
V
R
A
A
R
R
R
G
A
A
A
Q
P
Dog
Lupus familis
XP_546833
272
28271
C258
L
Y
P
V
L
Q
Q
C
L
V
R
A
A
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTW3
273
28352
C259
L
Y
P
V
L
Q
Q
C
L
V
R
A
A
R
R
Rat
Rattus norvegicus
XP_226471
312
32781
C298
L
Y
P
V
L
Q
Q
C
L
V
R
A
A
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6P0I8
271
29438
A257
L
Y
P
V
V
Q
Q
A
L
T
R
A
V
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609618
246
27003
S238
E
H
L
L
H
M
G
S
A
S
D
F
A
K
V
Honey Bee
Apis mellifera
XP_623498
273
30513
C263
I
C
P
V
L
Q
Q
C
L
V
K
T
I
M
K
Nematode Worm
Caenorhab. elegans
Q17533
240
26046
H230
L
A
V
V
A
Q
Q
H
L
K
A
C
A
P
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328307
263
28041
E256
I
L
R
S
C
L
K
E
A
A
S
A
S
K
D
Maize
Zea mays
NP_001168912
209
22466
D202
I
L
R
D
R
L
K
D
T
A
T
L
T
C
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P46948
246
27542
R239
L
R
K
H
A
Q
K
R
V
S
N
A
S
A
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
66.5
95.2
N.A.
91.5
80.4
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
30.8
35.9
26.1
N.A.
Protein Similarity:
100
99.6
66.5
95.5
N.A.
94.5
82.6
N.A.
N.A.
N.A.
N.A.
66.9
N.A.
46.6
56.7
42.2
N.A.
P-Site Identity:
100
100
13.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
60
N.A.
13.3
46.6
40
N.A.
P-Site Similarity:
100
100
26.6
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
86.6
N.A.
33.3
66.6
40
N.A.
Percent
Protein Identity:
26.8
28.3
N.A.
N.A.
23.5
N.A.
Protein Similarity:
43.3
42.6
N.A.
N.A.
40.4
N.A.
P-Site Identity:
6.6
0
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
33.3
13.3
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
24
8
0
8
16
16
16
70
62
8
0
% A
% Cys:
0
8
0
0
8
0
0
31
0
0
0
8
0
8
0
% C
% Asp:
0
0
0
8
0
0
0
8
0
0
8
0
0
0
8
% D
% Glu:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% G
% His:
0
8
0
8
8
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
24
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% I
% Lys:
0
0
8
0
0
0
24
0
0
8
8
0
0
24
16
% K
% Leu:
62
24
8
8
47
16
0
0
62
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
54
0
0
0
0
0
0
0
0
0
0
8
8
% P
% Gln:
0
0
0
0
0
70
62
0
0
0
0
0
0
8
0
% Q
% Arg:
0
8
16
8
8
0
8
16
8
0
47
0
0
39
47
% R
% Ser:
8
0
0
8
0
0
0
24
0
16
8
0
16
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
8
8
8
8
8
0
0
% T
% Val:
0
0
16
62
8
0
0
0
8
47
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
47
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _