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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EXOSC6 All Species: 21.52
Human Site: Y252 Identified Species: 39.44
UniProt: Q5RKV6 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5RKV6 NP_478126.1 272 28235 Y252 L E G C Q R L Y P V L Q Q S L
Chimpanzee Pan troglodytes XP_523406 272 28247 Y252 L E G C Q R L Y P V L Q Q S L
Rhesus Macaque Macaca mulatta XP_001101736 185 19058 L172 Y P V L Q Q S L V R A A R R R
Dog Lupus familis XP_546833 272 28271 Y252 L E G C Q R L Y P V L Q Q C L
Cat Felis silvestris
Mouse Mus musculus Q8BTW3 273 28352 Y253 L E G C Q R L Y P V L Q Q C L
Rat Rattus norvegicus XP_226471 312 32781 Y292 L E G C Q R L Y P V L Q Q C L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6P0I8 271 29438 Y251 M D G C H K L Y P V V Q Q A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609618 246 27003 H232 L E A A V K E H L L H M G S A
Honey Bee Apis mellifera XP_623498 273 30513 C257 T T V N K D I C P V L Q Q C L
Nematode Worm Caenorhab. elegans Q17533 240 26046 A224 A D V Y E C L A V V A Q Q H L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002328307 263 28041 L250 C S K L A K I L R S C L K E A
Maize Zea mays NP_001168912 209 22466 L196 C S K L G D I L R D R L K D T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P46948 246 27542 R233 D L M D E E L R K H A Q K R V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 66.5 95.2 N.A. 91.5 80.4 N.A. N.A. N.A. N.A. 46.6 N.A. 30.8 35.9 26.1 N.A.
Protein Similarity: 100 99.6 66.5 95.5 N.A. 94.5 82.6 N.A. N.A. N.A. N.A. 66.9 N.A. 46.6 56.7 42.2 N.A.
P-Site Identity: 100 100 6.6 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. N.A. 60 N.A. 20 40 33.3 N.A.
P-Site Similarity: 100 100 20 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. N.A. 93.3 N.A. 40 53.3 46.6 N.A.
Percent
Protein Identity: 26.8 28.3 N.A. N.A. 23.5 N.A.
Protein Similarity: 43.3 42.6 N.A. N.A. 40.4 N.A.
P-Site Identity: 0 0 N.A. N.A. 13.3 N.A.
P-Site Similarity: 20 13.3 N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 8 8 0 0 8 0 0 24 8 0 8 16 % A
% Cys: 16 0 0 47 0 8 0 8 0 0 8 0 0 31 0 % C
% Asp: 8 16 0 8 0 16 0 0 0 8 0 0 0 8 0 % D
% Glu: 0 47 0 0 16 8 8 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 47 0 8 0 0 0 0 0 0 0 8 0 0 % G
% His: 0 0 0 0 8 0 0 8 0 8 8 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 16 0 8 24 0 0 8 0 0 0 24 0 0 % K
% Leu: 47 8 0 24 0 0 62 24 8 8 47 16 0 0 62 % L
% Met: 8 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 0 0 0 0 0 0 54 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 47 8 0 0 0 0 0 70 62 0 0 % Q
% Arg: 0 0 0 0 0 39 0 8 16 8 8 0 8 16 8 % R
% Ser: 0 16 0 0 0 0 8 0 0 8 0 0 0 24 0 % S
% Thr: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % T
% Val: 0 0 24 0 8 0 0 0 16 62 8 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 8 0 0 0 47 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _