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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D4B
All Species:
28.18
Human Site:
S252
Identified Species:
62
UniProt:
Q5SQS7
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5SQS7
NP_001139191.1
431
51232
S252
K
G
T
V
A
G
L
S
S
M
F
R
E
L
G
Chimpanzee
Pan troglodytes
XP_521531
433
51331
S253
K
G
T
V
A
G
L
S
S
M
F
R
E
L
G
Rhesus Macaque
Macaca mulatta
XP_001087259
433
51270
S253
K
G
M
V
A
G
L
S
S
M
F
R
E
L
G
Dog
Lupus familis
XP_536404
488
56564
S309
K
G
T
V
A
G
L
S
S
M
F
Q
E
L
G
Cat
Felis silvestris
Mouse
Mus musculus
A6X942
431
51101
S252
K
G
T
V
A
G
L
S
T
M
F
Q
E
L
G
Rat
Rattus norvegicus
Q6AYC8
422
48504
L246
G
D
G
L
Q
N
P
L
T
G
P
Q
K
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507607
587
66688
S409
K
G
K
V
A
G
L
S
S
M
F
Q
G
I
G
Chicken
Gallus gallus
XP_001232928
425
50516
S251
K
G
R
V
A
D
L
S
N
L
F
Q
G
T
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689048
423
49636
S244
K
G
L
V
A
G
L
S
G
L
F
H
K
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_741483
533
60879
N316
R
K
A
R
E
A
E
N
A
K
R
E
L
A
Q
Sea Urchin
Strong. purpuratus
XP_781629
470
56428
H283
I
L
S
K
D
L
T
H
L
T
I
Q
E
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
96.3
68.4
N.A.
92.1
42.6
N.A.
54.1
71.9
N.A.
61.4
N.A.
N.A.
N.A.
27.9
38.9
Protein Similarity:
100
98.8
97.2
75.6
N.A.
95.5
61.4
N.A.
60.8
83.5
N.A.
76
N.A.
N.A.
N.A.
43.3
57.8
P-Site Identity:
100
100
93.3
93.3
N.A.
86.6
0
N.A.
73.3
53.3
N.A.
53.3
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
93.3
100
N.A.
100
26.6
N.A.
86.6
73.3
N.A.
66.6
N.A.
N.A.
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
73
10
0
0
10
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
10
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
10
0
0
0
0
10
55
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
73
0
0
0
0
% F
% Gly:
10
73
10
0
0
64
0
0
10
10
0
0
19
0
64
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
10
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% I
% Lys:
73
10
10
10
0
0
0
0
0
10
0
0
19
0
10
% K
% Leu:
0
10
10
10
0
10
73
10
10
19
0
0
10
46
10
% L
% Met:
0
0
10
0
0
0
0
0
0
55
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
10
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
10
0
0
0
10
0
0
10
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
55
0
0
10
% Q
% Arg:
10
0
10
10
0
0
0
0
0
0
10
28
0
0
0
% R
% Ser:
0
0
10
0
0
0
0
73
46
0
0
0
0
0
0
% S
% Thr:
0
0
37
0
0
0
10
0
19
10
0
0
0
19
0
% T
% Val:
0
0
0
73
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _