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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D4B
All Species:
13.64
Human Site:
S261
Identified Species:
30
UniProt:
Q5SQS7
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5SQS7
NP_001139191.1
431
51232
S261
M
F
R
E
L
G
Q
S
H
E
Q
E
A
R
L
Chimpanzee
Pan troglodytes
XP_521531
433
51331
S262
M
F
R
E
L
G
Q
S
H
E
Q
E
A
R
L
Rhesus Macaque
Macaca mulatta
XP_001087259
433
51270
S262
M
F
R
E
L
G
Q
S
H
E
Q
E
A
R
L
Dog
Lupus familis
XP_536404
488
56564
S318
M
F
Q
E
L
G
Q
S
H
E
Q
E
A
R
L
Cat
Felis silvestris
Mouse
Mus musculus
A6X942
431
51101
N261
M
F
Q
E
L
G
Q
N
H
E
Q
E
A
R
L
Rat
Rattus norvegicus
Q6AYC8
422
48504
P255
G
P
Q
K
P
K
R
P
P
L
P
P
K
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507607
587
66688
D418
M
F
Q
G
I
G
L
D
N
A
Q
G
E
N
V
Chicken
Gallus gallus
XP_001232928
425
50516
N260
L
F
Q
G
T
G
L
N
N
D
Q
E
T
K
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689048
423
49636
N253
L
F
H
K
T
H
L
N
G
S
G
H
N
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_741483
533
60879
A325
K
R
E
L
A
Q
K
A
R
E
K
H
Q
Q
M
Sea Urchin
Strong. purpuratus
XP_781629
470
56428
V292
T
I
Q
E
E
L
I
V
M
D
K
R
I
V
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
96.3
68.4
N.A.
92.1
42.6
N.A.
54.1
71.9
N.A.
61.4
N.A.
N.A.
N.A.
27.9
38.9
Protein Similarity:
100
98.8
97.2
75.6
N.A.
95.5
61.4
N.A.
60.8
83.5
N.A.
76
N.A.
N.A.
N.A.
43.3
57.8
P-Site Identity:
100
100
100
93.3
N.A.
86.6
0
N.A.
26.6
33.3
N.A.
13.3
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
53.3
73.3
N.A.
33.3
N.A.
N.A.
N.A.
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
10
0
10
0
0
46
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
19
0
0
0
0
0
% D
% Glu:
0
0
10
55
10
0
0
0
0
55
0
55
10
0
0
% E
% Phe:
0
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
19
0
64
0
0
10
0
10
10
0
0
0
% G
% His:
0
0
10
0
0
10
0
0
46
0
0
19
0
0
0
% H
% Ile:
0
10
0
0
10
0
10
0
0
0
0
0
10
0
0
% I
% Lys:
10
0
0
19
0
10
10
0
0
0
19
0
10
10
0
% K
% Leu:
19
0
0
10
46
10
28
0
0
10
0
0
0
0
55
% L
% Met:
55
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
28
19
0
0
0
10
10
0
% N
% Pro:
0
10
0
0
10
0
0
10
10
0
10
10
0
10
10
% P
% Gln:
0
0
55
0
0
10
46
0
0
0
64
0
10
10
10
% Q
% Arg:
0
10
28
0
0
0
10
0
10
0
0
10
0
55
10
% R
% Ser:
0
0
0
0
0
0
0
37
0
10
0
0
0
0
0
% S
% Thr:
10
0
0
0
19
0
0
0
0
0
0
0
10
0
0
% T
% Val:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _