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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D4B
All Species:
6.97
Human Site:
T59
Identified Species:
15.33
UniProt:
Q5SQS7
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5SQS7
NP_001139191.1
431
51232
T59
E
G
L
R
P
P
K
T
K
R
A
S
D
K
H
Chimpanzee
Pan troglodytes
XP_521531
433
51331
T59
E
G
L
R
P
P
K
T
K
R
A
A
S
D
K
Rhesus Macaque
Macaca mulatta
XP_001087259
433
51270
T59
K
G
L
R
P
T
K
T
K
R
A
A
S
D
K
Dog
Lupus familis
XP_536404
488
56564
V59
E
G
L
R
P
P
K
V
K
R
V
P
V
S
V
Cat
Felis silvestris
Mouse
Mus musculus
A6X942
431
51101
V59
E
G
L
R
P
A
K
V
K
R
A
S
N
K
H
Rat
Rattus norvegicus
Q6AYC8
422
48504
K59
L
P
V
K
S
R
P
K
K
E
N
G
K
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507607
587
66688
A170
Q
R
K
Q
N
V
W
A
V
D
H
P
F
A
W
Chicken
Gallus gallus
XP_001232928
425
50516
R59
M
L
T
K
T
A
R
R
K
Q
S
N
G
K
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689048
423
49636
G59
K
N
K
S
N
R
R
G
I
Q
W
L
L
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_741483
533
60879
K61
M
N
R
K
Q
K
K
K
G
L
R
W
L
T
G
Sea Urchin
Strong. purpuratus
XP_781629
470
56428
N59
K
K
V
P
K
K
G
N
K
K
V
V
W
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
96.3
68.4
N.A.
92.1
42.6
N.A.
54.1
71.9
N.A.
61.4
N.A.
N.A.
N.A.
27.9
38.9
Protein Similarity:
100
98.8
97.2
75.6
N.A.
95.5
61.4
N.A.
60.8
83.5
N.A.
76
N.A.
N.A.
N.A.
43.3
57.8
P-Site Identity:
100
73.3
60
60
N.A.
80
6.6
N.A.
0
13.3
N.A.
0
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
80
73.3
60
N.A.
86.6
20
N.A.
13.3
46.6
N.A.
20
N.A.
N.A.
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
19
0
10
0
0
37
19
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
0
0
10
19
0
% D
% Glu:
37
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
46
0
0
0
0
10
10
10
0
0
10
10
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
19
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% I
% Lys:
28
10
19
28
10
19
55
19
73
10
0
0
10
28
19
% K
% Leu:
10
10
46
0
0
0
0
0
0
10
0
10
19
10
0
% L
% Met:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
19
0
0
19
0
0
10
0
0
10
10
10
0
0
% N
% Pro:
0
10
0
10
46
28
10
0
0
0
0
19
0
0
0
% P
% Gln:
10
0
0
10
10
0
0
0
0
19
0
0
0
0
10
% Q
% Arg:
0
10
10
46
0
19
19
10
0
46
10
0
0
0
10
% R
% Ser:
0
0
0
10
10
0
0
0
0
0
10
19
19
19
10
% S
% Thr:
0
0
10
0
10
10
0
28
0
0
0
0
0
10
0
% T
% Val:
0
0
19
0
0
10
0
19
10
0
19
10
10
0
19
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
10
10
10
0
10
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _