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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIATL1 All Species: 21.82
Human Site: S494 Identified Species: 40
UniProt: Q5SR56 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5SR56 NP_115947.2 506 54545 S494 D S S I W E L S S F E E P G N
Chimpanzee Pan troglodytes XP_520704 440 47541 S428 D S S I W E L S S F E E P G N
Rhesus Macaque Macaca mulatta XP_001104588 506 54465 S494 D S S I W E L S S F E E P G N
Dog Lupus familis XP_533564 515 55621 S503 D N S I W E L S S F E E S G N
Cat Felis silvestris
Mouse Mus musculus Q8CIA9 507 55084 S496 D S S I W E L S F E E P G N Q
Rat Rattus norvegicus B2RYH9 507 54917 S496 D S N I W E L S S E E P G N Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512475 466 50593 E455 H S P Q A P G E A K E P L L Q
Chicken Gallus gallus NP_001034410 492 52978 S480 H S P Q A G A S D G K E P L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002663499 486 52565 E475 T P L P G S D E D F E P L L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728811 680 72850 L668 G H K A P S S L A P L I R S D
Honey Bee Apis mellifera XP_624637 518 55806 K500 G D K L G S G K G K I G P L S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780651 530 56878 I518 L L T D V D S I G I E P S A V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q04301 562 62621 S548 A A V G I V L S L Y L V K H T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.7 99.4 91.6 N.A. 89.7 89.7 N.A. 66.2 70.5 N.A. 67.9 N.A. 43.5 55.5 N.A. 54.9
Protein Similarity: 100 86.9 99.8 94.3 N.A. 93.2 93.4 N.A. 76 81.2 N.A. 78.8 N.A. 55.5 72.7 N.A. 69.2
P-Site Identity: 100 100 100 86.6 N.A. 60 60 N.A. 13.3 26.6 N.A. 13.3 N.A. 0 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 60 66.6 N.A. 20 33.3 N.A. 13.3 N.A. 13.3 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 36.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 16 0 8 0 16 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 47 8 0 8 0 8 8 0 16 0 0 0 0 0 8 % D
% Glu: 0 0 0 0 0 47 0 16 0 16 70 39 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 8 39 0 0 0 0 0 % F
% Gly: 16 0 0 8 16 8 16 0 16 8 0 8 16 31 0 % G
% His: 16 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 47 8 0 0 8 0 8 8 8 0 0 0 % I
% Lys: 0 0 16 0 0 0 0 8 0 16 8 0 8 0 0 % K
% Leu: 8 8 8 8 0 0 54 8 8 0 16 0 16 31 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 0 0 0 0 0 0 16 31 % N
% Pro: 0 8 16 8 8 8 0 0 0 8 0 39 39 0 0 % P
% Gln: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 24 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % R
% Ser: 0 54 39 0 0 24 16 62 39 0 0 0 16 8 8 % S
% Thr: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % T
% Val: 0 0 8 0 8 8 0 0 0 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 47 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _