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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
THEM4
All Species:
9.7
Human Site:
Y184
Identified Species:
23.7
UniProt:
Q5T1C6
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5T1C6
NP_444283.2
240
27130
Y184
T
A
N
L
N
I
N
Y
K
R
P
I
P
L
C
Chimpanzee
Pan troglodytes
XP_513806
240
27259
Y184
T
A
N
L
N
I
N
Y
K
R
P
I
P
L
C
Rhesus Macaque
Macaca mulatta
XP_001108917
116
12553
Y60
T
A
N
L
N
I
N
Y
K
R
P
I
P
L
C
Dog
Lupus familis
XP_851465
331
35313
F276
T
A
N
L
N
I
N
F
R
R
P
I
P
L
C
Cat
Felis silvestris
Mouse
Mus musculus
Q3UUI3
230
26013
K175
A
N
L
N
I
T
Y
K
K
P
I
P
L
L
S
Rat
Rattus norvegicus
Q566R0
230
26071
K175
A
N
L
N
I
D
Y
K
K
P
I
P
L
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512354
152
16267
S97
G
T
C
A
I
L
V
S
G
V
V
M
T
A
N
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6GLK2
222
24962
L167
G
G
V
M
T
A
N
L
T
V
D
Y
K
N
P
Zebra Danio
Brachydanio rerio
NP_001074103
222
24562
R167
A
N
L
N
I
N
Y
R
S
P
V
P
L
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188893
199
21898
I144
P
L
P
V
N
S
T
I
I
I
E
T
V
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97
45.4
49.8
N.A.
68.3
69.1
N.A.
36.6
N.A.
47.9
38.7
N.A.
N.A.
N.A.
N.A.
30.8
Protein Similarity:
100
97.9
48.3
58.6
N.A.
81.6
82
N.A.
50
N.A.
65.8
54.5
N.A.
N.A.
N.A.
N.A.
50.4
P-Site Identity:
100
100
100
86.6
N.A.
13.3
13.3
N.A.
0
N.A.
6.6
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
13.3
13.3
N.A.
13.3
N.A.
13.3
0
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
40
0
10
0
10
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
40
% C
% Asp:
0
0
0
0
0
10
0
0
0
0
10
0
0
0
10
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
20
10
0
0
0
0
0
0
10
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
40
40
0
10
10
10
20
40
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
20
50
0
0
0
10
0
0
% K
% Leu:
0
10
30
40
0
10
0
10
0
0
0
0
30
60
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
30
40
30
50
10
50
0
0
0
0
0
0
10
10
% N
% Pro:
10
0
10
0
0
0
0
0
0
30
40
30
40
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
10
40
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
10
0
10
10
0
0
0
0
0
30
% S
% Thr:
40
10
0
0
10
10
10
0
10
0
0
10
10
0
0
% T
% Val:
0
0
10
10
0
0
10
0
0
20
20
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
30
30
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _