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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMTC4
All Species:
23.33
Human Site:
S433
Identified Species:
57.04
UniProt:
Q5T4D3
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5T4D3
NP_001073137.1
741
82991
S433
T
F
G
F
G
A
L
S
K
H
T
K
K
K
K
Chimpanzee
Pan troglodytes
XP_509717
790
88939
S482
T
F
G
F
G
A
L
S
K
H
T
K
K
K
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534177
1013
112724
S705
T
F
G
F
G
A
L
S
K
H
T
K
K
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG19
741
82944
S433
T
F
G
F
G
A
L
S
R
H
T
K
K
K
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416968
790
89162
S431
T
Y
G
F
S
L
L
S
K
Q
A
K
K
K
K
Frog
Xenopus laevis
Q6DCD5
836
94386
Y443
T
V
G
A
R
A
L
Y
I
K
A
Q
K
N
I
Zebra Danio
Brachydanio rerio
NP_001166973
739
83162
S430
A
Y
A
V
G
Y
C
S
C
H
W
R
K
H
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VF81
705
80433
T398
Y
D
S
S
T
E
N
T
H
W
R
T
A
L
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20144
690
77719
S405
T
L
I
L
L
L
I
S
K
T
Y
R
R
S
G
Sea Urchin
Strong. purpuratus
XP_787838
666
75633
R395
N
S
E
W
S
T
E
R
R
L
Y
R
S
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.9
N.A.
68.3
N.A.
90.6
N.A.
N.A.
N.A.
79.7
33.7
68.2
N.A.
37.7
N.A.
36
39.4
Protein Similarity:
100
90.8
N.A.
70.7
N.A.
94.7
N.A.
N.A.
N.A.
87
51.6
81.1
N.A.
55.8
N.A.
53.7
57.3
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
N.A.
N.A.
N.A.
66.6
33.3
33.3
N.A.
0
N.A.
20
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
N.A.
73.3
40
46.6
N.A.
13.3
N.A.
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
10
0
50
0
0
0
0
20
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
0
0
10
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
40
0
50
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
60
0
50
0
0
0
0
0
0
0
0
10
10
% G
% His:
0
0
0
0
0
0
0
0
10
50
0
0
0
10
0
% H
% Ile:
0
0
10
0
0
0
10
0
10
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
50
10
0
50
70
50
60
% K
% Leu:
0
10
0
10
10
20
60
0
0
10
0
0
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% Q
% Arg:
0
0
0
0
10
0
0
10
20
0
10
30
10
0
10
% R
% Ser:
0
10
10
10
20
0
0
70
0
0
0
0
10
10
0
% S
% Thr:
70
0
0
0
10
10
0
10
0
10
40
10
0
0
0
% T
% Val:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
10
0
0
0
0
0
10
10
0
0
0
0
% W
% Tyr:
10
20
0
0
0
10
0
10
0
0
20
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _