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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLK4
All Species:
9.09
Human Site:
S167
Identified Species:
25
UniProt:
Q5TCX8
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5TCX8
NP_115811.2
1036
113957
S167
D
A
A
A
A
A
E
S
V
R
R
E
A
R
L
Chimpanzee
Pan troglodytes
XP_001146659
1107
121909
N190
D
I
S
Q
T
I
E
N
V
R
Q
E
A
K
L
Rhesus Macaque
Macaca mulatta
XP_001103092
1040
114439
S171
D
A
A
A
A
A
E
S
V
R
R
E
A
R
L
Dog
Lupus familis
XP_547887
1216
135201
N299
D
I
S
Q
T
I
E
N
V
R
Q
E
A
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDG6
1002
110093
S153
D
A
A
A
A
A
E
S
V
R
R
E
A
R
L
Rat
Rattus norvegicus
Q66HA1
850
93091
G127
L
E
E
V
I
G
I
G
G
F
G
K
V
Y
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q7T2V3
1005
111856
N161
D
I
N
V
T
A
E
N
V
R
Q
E
A
K
I
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
N185
D
M
Q
R
M
R
D
N
V
L
Q
E
A
K
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O01700
928
103465
A160
Q
L
E
N
R
T
V
A
V
K
K
V
N
Q
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
49.1
95
44.7
N.A.
69.5
45.7
N.A.
N.A.
N.A.
47.2
N.A.
N.A.
31.2
N.A.
20.4
N.A.
Protein Similarity:
100
63.9
96.1
57.8
N.A.
76.9
58.2
N.A.
N.A.
N.A.
62.5
N.A.
N.A.
45.2
N.A.
35.8
N.A.
P-Site Identity:
100
46.6
100
46.6
N.A.
100
0
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
33.3
N.A.
13.3
N.A.
P-Site Similarity:
100
73.3
100
73.3
N.A.
100
6.6
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
60
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
34
34
34
34
45
0
12
0
0
0
0
78
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
78
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% D
% Glu:
0
12
23
0
0
0
67
0
0
0
0
78
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
12
0
12
12
0
12
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
34
0
0
12
23
12
0
0
0
0
0
0
0
12
% I
% Lys:
0
0
0
0
0
0
0
0
0
12
12
12
0
45
0
% K
% Leu:
12
12
0
0
0
0
0
0
0
12
0
0
0
0
78
% L
% Met:
0
12
0
0
12
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
12
12
0
0
0
45
0
0
0
0
12
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
0
12
23
0
0
0
0
0
0
45
0
0
12
0
% Q
% Arg:
0
0
0
12
12
12
0
0
0
67
34
0
0
34
12
% R
% Ser:
0
0
23
0
0
0
0
34
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
34
12
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
23
0
0
12
0
89
0
0
12
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _