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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES3
All Species:
1.21
Human Site:
S25
Identified Species:
2.67
UniProt:
Q5TGS1
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.4
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5TGS1
NP_001019769.1
186
19968
S25
S
L
L
E
K
H
Y
S
H
Q
I
R
K
R
K
Chimpanzee
Pan troglodytes
XP_001162588
239
25232
K25
T
L
I
L
D
A
L
K
K
D
S
S
R
H
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546749
200
21060
S37
R
R
A
R
I
N
V
S
L
E
Q
L
K
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61657
175
19275
L16
I
N
V
S
L
E
Q
L
R
S
L
L
E
R
H
Rat
Rattus norvegicus
Q04667
175
19118
L16
I
N
L
S
L
E
Q
L
R
S
L
L
E
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511924
287
29320
K48
T
L
I
L
D
A
L
K
K
D
S
S
R
H
S
Chicken
Gallus gallus
O57337
290
31053
K67
M
L
I
L
D
A
L
K
K
D
S
S
R
H
S
Frog
Xenopus laevis
Q8AVU4
267
28644
K66
T
L
I
L
D
A
L
K
K
D
S
S
R
H
S
Zebra Danio
Brachydanio rerio
Q9I9L0
324
34311
E80
R
L
V
P
T
A
F
E
K
Q
G
S
A
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
K72
S
L
I
L
E
A
M
K
K
D
P
A
R
H
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175739
383
41428
N62
N
L
V
L
D
A
L
N
K
N
N
P
R
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
N.A.
67
N.A.
65.5
63.9
N.A.
25.7
24.1
25.8
22.5
N.A.
20.9
N.A.
N.A.
21.9
Protein Similarity:
100
39.7
N.A.
70
N.A.
70.4
72
N.A.
35.8
36.2
35.9
33.3
N.A.
29.6
N.A.
N.A.
31.3
P-Site Identity:
100
6.6
N.A.
13.3
N.A.
6.6
13.3
N.A.
6.6
6.6
6.6
13.3
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
26.6
N.A.
26.6
N.A.
26.6
26.6
N.A.
26.6
20
26.6
33.3
N.A.
33.3
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
64
0
0
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
46
0
0
0
0
46
0
0
0
0
0
% D
% Glu:
0
0
0
10
10
19
0
10
0
10
0
0
19
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
10
0
0
10
0
0
0
0
55
19
% H
% Ile:
19
0
46
0
10
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
0
10
0
0
46
64
0
0
0
19
10
10
% K
% Leu:
0
73
19
55
19
0
46
19
10
0
19
28
0
0
19
% L
% Met:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
10
19
0
0
0
10
0
10
0
10
10
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
10
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
19
0
0
19
10
0
0
0
0
% Q
% Arg:
19
10
0
10
0
0
0
0
19
0
0
10
55
28
0
% R
% Ser:
19
0
0
19
0
0
0
19
0
19
37
46
0
10
46
% S
% Thr:
28
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
28
0
0
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _