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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARFGEF3
All Species:
20.91
Human Site:
S295
Identified Species:
46
UniProt:
Q5TH69
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5TH69
NP_065073.3
2177
240652
S295
S
L
E
S
D
S
A
S
P
G
V
S
D
H
G
Chimpanzee
Pan troglodytes
XP_518767
2177
240619
S295
S
L
E
S
D
S
A
S
P
G
V
S
D
H
G
Rhesus Macaque
Macaca mulatta
XP_001095348
2107
232862
V271
S
V
D
S
M
K
P
V
L
Q
S
L
Y
H
R
Dog
Lupus familis
XP_541124
2192
241439
S295
G
I
E
S
D
S
A
S
P
G
V
S
D
H
G
Cat
Felis silvestris
Mouse
Mus musculus
Q3UGY8
2170
240072
S295
S
M
E
S
D
S
A
S
L
G
V
S
D
H
G
Rat
Rattus norvegicus
XP_218665
2170
240113
S295
S
M
E
S
D
S
A
S
L
G
V
S
D
H
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419718
2177
241948
S292
C
L
E
A
D
S
P
S
S
G
V
S
D
H
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001921357
2181
240848
G296
Q
D
S
V
S
A
P
G
S
A
V
L
D
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001096888
2070
230154
K282
P
G
R
I
N
L
D
K
K
F
T
Y
K
L
V
Honey Bee
Apis mellifera
XP_392019
2181
244055
E278
D
K
T
F
T
S
R
E
G
K
E
N
E
I
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193250
1550
170185
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
95.7
93.1
N.A.
92.8
92
N.A.
N.A.
84.8
N.A.
73.2
N.A.
22.8
32.4
N.A.
20.3
Protein Similarity:
100
99.9
96.2
96.1
N.A.
96
95.8
N.A.
N.A.
92.4
N.A.
84.1
N.A.
41.4
52.6
N.A.
35.8
P-Site Identity:
100
100
20
86.6
N.A.
86.6
86.6
N.A.
N.A.
73.3
N.A.
20
N.A.
0
13.3
N.A.
0
P-Site Similarity:
100
100
33.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
80
N.A.
26.6
N.A.
6.6
26.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
46
0
0
10
0
0
0
0
0
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
10
0
55
0
10
0
0
0
0
0
64
0
0
% D
% Glu:
0
0
55
0
0
0
0
10
0
0
10
0
10
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
10
10
0
0
0
0
0
10
10
55
0
0
0
0
73
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
64
0
% H
% Ile:
0
10
0
10
0
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
10
0
0
0
10
0
10
10
10
0
0
10
0
0
% K
% Leu:
0
28
0
0
0
10
0
0
28
0
0
19
0
10
0
% L
% Met:
0
19
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% N
% Pro:
10
0
0
0
0
0
28
0
28
0
0
0
0
0
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% Q
% Arg:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
10
% R
% Ser:
46
0
10
55
10
64
0
55
19
0
10
55
0
0
0
% S
% Thr:
0
0
10
0
10
0
0
0
0
0
10
0
0
0
0
% T
% Val:
0
10
0
10
0
0
0
10
0
0
64
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _