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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARFGEF3
All Species:
23.33
Human Site:
T2027
Identified Species:
51.33
UniProt:
Q5TH69
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5TH69
NP_065073.3
2177
240652
T2027
K
T
I
S
K
L
M
T
E
Y
K
K
R
K
Q
Chimpanzee
Pan troglodytes
XP_518767
2177
240619
T2027
K
T
I
S
K
L
M
T
E
Y
K
K
R
K
Q
Rhesus Macaque
Macaca mulatta
XP_001095348
2107
232862
T1957
K
T
I
S
K
L
M
T
E
Y
K
K
R
K
Q
Dog
Lupus familis
XP_541124
2192
241439
T2042
R
T
I
S
K
L
M
T
E
Y
K
K
R
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q3UGY8
2170
240072
T2020
K
T
I
S
K
L
M
T
E
Y
K
K
R
R
Q
Rat
Rattus norvegicus
XP_218665
2170
240113
T2020
K
T
I
S
K
L
M
T
E
Y
K
K
R
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419718
2177
241948
M2026
D
K
T
I
S
K
F
M
T
E
Y
K
K
R
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001921357
2181
240848
I2028
K
T
I
T
K
L
M
I
E
Y
K
K
R
K
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001096888
2070
230154
G1933
P
M
C
I
S
L
N
G
N
G
D
A
E
M
T
Honey Bee
Apis mellifera
XP_392019
2181
244055
S2027
G
S
T
V
S
G
S
S
N
D
L
D
L
S
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193250
1550
170185
K1415
Q
I
Y
T
V
A
T
K
K
A
I
K
S
L
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
95.7
93.1
N.A.
92.8
92
N.A.
N.A.
84.8
N.A.
73.2
N.A.
22.8
32.4
N.A.
20.3
Protein Similarity:
100
99.9
96.2
96.1
N.A.
96
95.8
N.A.
N.A.
92.4
N.A.
84.1
N.A.
41.4
52.6
N.A.
35.8
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
N.A.
86.6
N.A.
6.6
0
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
26.6
N.A.
93.3
N.A.
6.6
13.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
0
10
0
10
0
0
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
0
10
10
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
64
10
0
0
10
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
10
0
10
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
64
19
0
0
0
10
0
0
10
0
0
0
0
% I
% Lys:
55
10
0
0
64
10
0
10
10
0
64
82
10
46
10
% K
% Leu:
0
0
0
0
0
73
0
0
0
0
10
0
10
10
0
% L
% Met:
0
10
0
0
0
0
64
10
0
0
0
0
0
10
10
% M
% Asn:
0
0
0
0
0
0
10
0
19
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
64
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
64
28
0
% R
% Ser:
0
10
0
55
28
0
10
10
0
0
0
0
10
10
0
% S
% Thr:
0
64
19
19
0
0
10
55
10
0
0
0
0
0
10
% T
% Val:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
64
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _