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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HECTD2
All Species:
20
Human Site:
T259
Identified Species:
40
UniProt:
Q5U5R9
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5U5R9
NP_877497.2
776
88122
T259
H
L
L
R
Q
I
A
T
L
V
E
A
D
H
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088322
776
88225
T259
H
L
L
R
Q
I
A
T
L
V
E
A
D
H
H
Dog
Lupus familis
XP_543924
776
88394
T259
H
L
L
R
Q
I
A
T
L
V
E
A
D
H
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8CDU6
774
87768
T257
H
L
L
R
Q
I
A
T
L
V
E
A
D
H
H
Rat
Rattus norvegicus
Q5PQN1
1057
118521
F339
T
S
N
R
K
S
P
F
T
V
K
G
N
W
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506979
739
84811
Q241
H
W
F
K
N
L
S
Q
K
R
F
K
Q
L
V
Chicken
Gallus gallus
XP_424632
794
90010
A277
H
L
L
R
Q
I
A
A
L
T
E
A
D
H
H
Frog
Xenopus laevis
Q2TAS2
751
86306
T245
H
R
N
Y
M
S
R
T
H
L
H
T
P
P
D
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
T245
H
R
N
Y
M
S
R
T
H
L
H
T
P
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
S396
Q
P
E
I
S
A
T
S
L
Q
N
D
L
R
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782992
776
87934
T257
H
L
L
R
Q
L
S
T
L
A
D
N
D
H
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40985
892
103438
Q273
K
N
V
F
E
T
Q
Q
I
R
A
V
S
Y
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
92.6
N.A.
89.1
26
N.A.
80.4
80.8
22.8
22.4
N.A.
21.5
N.A.
N.A.
52.7
Protein Similarity:
100
N.A.
99
96.3
N.A.
94.7
40.4
N.A.
86
88.2
39.5
39.2
N.A.
37.8
N.A.
N.A.
69.9
P-Site Identity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
6.6
86.6
13.3
13.3
N.A.
6.6
N.A.
N.A.
66.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
33.3
N.A.
26.6
86.6
20
20
N.A.
13.3
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
42
9
0
9
9
42
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
9
9
50
0
17
% D
% Glu:
0
0
9
0
9
0
0
0
0
0
42
0
0
0
9
% E
% Phe:
0
0
9
9
0
0
0
9
0
0
9
0
0
0
9
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% G
% His:
75
0
0
0
0
0
0
0
17
0
17
0
0
50
50
% H
% Ile:
0
0
0
9
0
42
0
0
9
0
0
0
0
0
0
% I
% Lys:
9
0
0
9
9
0
0
0
9
0
9
9
0
0
0
% K
% Leu:
0
50
50
0
0
17
0
0
59
17
0
0
9
9
0
% L
% Met:
0
0
0
0
17
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
25
0
9
0
0
0
0
0
9
9
9
0
0
% N
% Pro:
0
9
0
0
0
0
9
0
0
0
0
0
17
17
9
% P
% Gln:
9
0
0
0
50
0
9
17
0
9
0
0
9
0
0
% Q
% Arg:
0
17
0
59
0
0
17
0
0
17
0
0
0
9
0
% R
% Ser:
0
9
0
0
9
25
17
9
0
0
0
0
9
0
0
% S
% Thr:
9
0
0
0
0
9
9
59
9
9
0
17
0
0
0
% T
% Val:
0
0
9
0
0
0
0
0
0
42
0
9
0
0
9
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
0
17
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _