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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HECTD2
All Species:
22.73
Human Site:
T424
Identified Species:
45.45
UniProt:
Q5U5R9
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5U5R9
NP_877497.2
776
88122
T424
L
N
M
K
V
R
R
T
H
L
V
S
D
S
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088322
776
88225
T424
L
N
M
K
V
R
R
T
H
L
V
S
D
S
L
Dog
Lupus familis
XP_543924
776
88394
T424
L
N
M
K
V
R
R
T
H
L
V
S
D
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CDU6
774
87768
T422
L
N
M
K
V
R
R
T
H
L
V
S
D
S
L
Rat
Rattus norvegicus
Q5PQN1
1057
118521
I625
I
H
E
V
Q
E
L
I
D
I
R
N
D
Y
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506979
739
84811
R399
D
S
L
D
E
L
T
R
K
T
A
D
L
K
K
Chicken
Gallus gallus
XP_424632
794
90010
T442
L
N
V
K
V
R
R
T
H
L
V
S
D
S
L
Frog
Xenopus laevis
Q2TAS2
751
86306
E404
R
I
E
V
S
R
E
E
I
F
E
E
S
Y
R
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
A407
L
S
Q
Q
Q
P
Q
A
G
H
C
R
I
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
V623
P
N
I
A
G
Q
A
V
P
Y
S
R
D
Y
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782992
776
87934
S423
L
N
L
K
V
R
R
S
H
L
V
S
D
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40985
892
103438
D528
F
K
I
K
V
R
R
D
V
I
S
H
D
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
92.6
N.A.
89.1
26
N.A.
80.4
80.8
22.8
22.4
N.A.
21.5
N.A.
N.A.
52.7
Protein Similarity:
100
N.A.
99
96.3
N.A.
94.7
40.4
N.A.
86
88.2
39.5
39.2
N.A.
37.8
N.A.
N.A.
69.9
P-Site Identity:
100
N.A.
100
100
N.A.
100
6.6
N.A.
0
93.3
6.6
6.6
N.A.
13.3
N.A.
N.A.
86.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
40
N.A.
13.3
100
6.6
33.3
N.A.
26.6
N.A.
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
9
9
0
0
9
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
9
0
0
9
0
0
0
9
9
0
0
9
75
0
0
% D
% Glu:
0
0
17
0
9
9
9
9
0
0
9
9
0
9
0
% E
% Phe:
9
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
0
% G
% His:
0
9
0
0
0
0
0
0
50
9
0
9
0
0
0
% H
% Ile:
9
9
17
0
0
0
0
9
9
17
0
0
9
0
9
% I
% Lys:
0
9
0
59
0
0
0
0
9
0
0
0
0
9
17
% K
% Leu:
59
0
17
0
0
9
9
0
0
50
0
0
9
0
59
% L
% Met:
0
0
34
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
59
0
0
0
0
0
0
0
0
0
9
0
0
0
% N
% Pro:
9
0
0
0
0
9
0
0
9
0
0
0
0
0
0
% P
% Gln:
0
0
9
9
17
9
9
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
0
0
0
67
59
9
0
0
9
17
0
0
9
% R
% Ser:
0
17
0
0
9
0
0
9
0
0
17
50
9
59
0
% S
% Thr:
0
0
0
0
0
0
9
42
0
9
0
0
0
0
0
% T
% Val:
0
0
9
17
59
0
0
9
9
0
50
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
25
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _