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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SHE All Species: 9.7
Human Site: S278 Identified Species: 26.67
UniProt: Q5VZ18 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5VZ18 NP_001010846.1 495 53950 S278 E T L A K R R S S K D L L G K
Chimpanzee Pan troglodytes XP_524890 419 46005 K209 S S K D L L G K P P Q L Y D T
Rhesus Macaque Macaca mulatta XP_001111408 422 46812 S212 E W K K E R I S K A F A V D I
Dog Lupus familis XP_855101 449 48944 S239 E T L A K R R S S K E L L G K
Cat Felis silvestris
Mouse Mus musculus Q8BSD5 492 53334 S281 A T A K R R S S K D L L G K P
Rat Rattus norvegicus XP_001062249 500 54065 S289 A T A K R R S S K D L L G K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521547 300 33125 K90 Y D Q P W E W K K E R I S K A
Chicken Gallus gallus XP_413725 381 42036 I171 W E W K K E R I S K A F A V E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_689987 438 48360 Y228 G S G P P Q I Y D V P Y E E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.2 28 77.5 N.A. 83.6 82.1 N.A. 27.6 26.4 N.A. 46.8 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 84.4 42.8 84.2 N.A. 88 86.4 N.A. 39.5 42.4 N.A. 60 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 20 93.3 N.A. 26.6 26.6 N.A. 0 26.6 N.A. 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 33.3 100 N.A. 33.3 33.3 N.A. 13.3 33.3 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 23 0 23 23 0 0 0 0 0 12 12 12 12 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 0 12 0 0 0 0 12 23 12 0 0 23 0 % D
% Glu: 34 12 0 0 12 23 0 0 0 12 12 0 12 12 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 12 12 0 0 0 % F
% Gly: 12 0 12 0 0 0 12 0 0 0 0 0 23 23 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 23 12 0 0 0 12 0 0 12 % I
% Lys: 0 0 23 45 34 0 0 23 45 34 0 0 0 34 23 % K
% Leu: 0 0 23 0 12 12 0 0 0 0 23 56 23 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 23 12 0 0 0 12 12 12 0 0 0 23 % P
% Gln: 0 0 12 0 0 12 0 0 0 0 12 0 0 0 0 % Q
% Arg: 0 0 0 0 23 56 34 0 0 0 12 0 0 0 0 % R
% Ser: 12 23 0 0 0 0 23 56 34 0 0 0 12 0 0 % S
% Thr: 0 45 0 0 0 0 0 0 0 0 0 0 0 0 12 % T
% Val: 0 0 0 0 0 0 0 0 0 12 0 0 12 12 12 % V
% Trp: 12 12 12 0 12 0 12 0 0 0 0 0 0 0 0 % W
% Tyr: 12 0 0 0 0 0 0 12 0 0 0 12 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _