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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAPDC1A All Species: 10
Human Site: S171 Identified Species: 15.71
UniProt: Q5VZY2 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5VZY2 NP_001025230.1 271 30395 S171 K L H C F T E S G R G K S W R
Chimpanzee Pan troglodytes XP_001170623 223 25141 F124 A G L A F A S F Y L A G K L H
Rhesus Macaque Macaca mulatta XP_001092746 343 37863 H230 R K S F P S G H S S F A F A G
Dog Lupus familis XP_535038 333 36609 S233 K L H C F T E S G R G K S W R
Cat Felis silvestris
Mouse Mus musculus Q0VBU9 271 30425 S171 K L H C F T E S G R G K S W R
Rat Rattus norvegicus O08564 282 31978 S169 E G R L S F Y S G H S S F S M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514919 461 51675 N177 K L H C F T E N G R G R S W R
Chicken Gallus gallus XP_426544 322 36285 N222 K L H C F T E N G R G K S W R
Frog Xenopus laevis Q6GQ62 226 25153 A127 G F T A L Y L A G K L R C F S
Zebra Danio Brachydanio rerio XP_002664129 282 31516 A178 K L Q C F T D A G R G R S W R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623887 268 30640 I168 F G F I A L Y I A G K L H T F
Nematode Worm Caenorhab. elegans Q10022 341 39009 N222 R L G P V L N N R I V V P I S
Sea Urchin Strong. purpuratus XP_787511 258 29394 R158 K L H T F E S R G R G V G W R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XI60 290 32684 D190 S G K I R V F D Q R G H V A K
Baker's Yeast Sacchar. cerevisiae Q05521 289 33495 Q187 L Y F W L C G Q L L T E S P L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.2 48 77.7 N.A. 99.2 25.5 N.A. 48.1 77.3 52.4 71.2 N.A. N.A. 47.9 24.3 46.1
Protein Similarity: 100 64.9 60 79.8 N.A. 99.2 41.1 N.A. 53.3 80.4 63.4 83.6 N.A. N.A. 66.7 39.8 64.2
P-Site Identity: 100 6.6 0 100 N.A. 100 13.3 N.A. 86.6 93.3 6.6 73.3 N.A. N.A. 0 6.6 60
P-Site Similarity: 100 6.6 13.3 100 N.A. 100 20 N.A. 100 100 33.3 93.3 N.A. N.A. 0 20 60
Percent
Protein Identity: N.A. N.A. N.A. 36.5 31.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.4 50.5 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 14 7 7 0 14 7 0 7 7 0 14 0 % A
% Cys: 0 0 0 40 0 7 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % D
% Glu: 7 0 0 0 0 7 34 0 0 0 0 7 0 0 0 % E
% Phe: 7 7 14 7 54 7 7 7 0 0 7 0 14 7 7 % F
% Gly: 7 27 7 0 0 0 14 0 60 7 54 7 7 0 7 % G
% His: 0 0 40 0 0 0 0 7 0 7 0 7 7 0 7 % H
% Ile: 0 0 0 14 0 0 0 7 0 7 0 0 0 7 0 % I
% Lys: 47 7 7 0 0 0 0 0 0 7 7 27 7 0 7 % K
% Leu: 7 54 7 7 14 14 7 0 7 14 7 7 0 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 7 20 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 7 0 0 0 0 0 0 0 7 7 0 % P
% Gln: 0 0 7 0 0 0 0 7 7 0 0 0 0 0 0 % Q
% Arg: 14 0 7 0 7 0 0 7 7 54 0 20 0 0 47 % R
% Ser: 7 0 7 0 7 7 14 27 7 7 7 7 47 7 14 % S
% Thr: 0 0 7 7 0 40 0 0 0 0 7 0 0 7 0 % T
% Val: 0 0 0 0 7 7 0 0 0 0 7 14 7 0 0 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 47 0 % W
% Tyr: 0 7 0 0 0 7 14 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _