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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAPDC1A All Species: 25.76
Human Site: T78 Identified Species: 40.48
UniProt: Q5VZY2 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5VZY2 NP_001025230.1 271 30395 T78 I I R R T D K T E I K E A F L
Chimpanzee Pan troglodytes XP_001170623 223 25141 I31 F L S P L S L I F L A K F L K
Rhesus Macaque Macaca mulatta XP_001092746 343 37863 P137 A E Y F P T K P M F V I A F L
Dog Lupus familis XP_535038 333 36609 T140 I I R R T D K T E I K E A F L
Cat Felis silvestris
Mouse Mus musculus Q0VBU9 271 30425 T78 I I R R T D K T E I K E A F L
Rat Rattus norvegicus O08564 282 31978 T76 I V M I T G E T L S V Y F N V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514919 461 51675 T84 I I R R T D K T E I K E A F L
Chicken Gallus gallus XP_426544 322 36285 T129 I I R R T D K T E I K E A F L
Frog Xenopus laevis Q6GQ62 226 25153 A34 P L S V V A L A R L F W K A D
Zebra Danio Brachydanio rerio XP_002664129 282 31516 T85 I I Q R T D R T E I K E A C L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623887 268 30640 F75 T M P V I V I F C V F L V Y K
Nematode Worm Caenorhab. elegans Q10022 341 39009 S129 L L T Y F G Y S Q I G F V M N
Sea Urchin Strong. purpuratus XP_787511 258 29394 I65 V P L C V I T I F S L M R K D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XI60 290 32684 H97 R N D V Y D L H H A I L G L L
Baker's Yeast Sacchar. cerevisiae Q05521 289 33495 F94 A D R R H L I F I L Y T S L L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.2 48 77.7 N.A. 99.2 25.5 N.A. 48.1 77.3 52.4 71.2 N.A. N.A. 47.9 24.3 46.1
Protein Similarity: 100 64.9 60 79.8 N.A. 99.2 41.1 N.A. 53.3 80.4 63.4 83.6 N.A. N.A. 66.7 39.8 64.2
P-Site Identity: 100 0 26.6 100 N.A. 100 20 N.A. 100 100 0 80 N.A. N.A. 0 6.6 0
P-Site Similarity: 100 20 26.6 100 N.A. 100 40 N.A. 100 100 13.3 93.3 N.A. N.A. 20 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 36.5 31.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.4 50.5 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 0 0 0 7 0 7 0 7 7 0 47 7 0 % A
% Cys: 0 0 0 7 0 0 0 0 7 0 0 0 0 7 0 % C
% Asp: 0 7 7 0 0 47 0 0 0 0 0 0 0 0 14 % D
% Glu: 0 7 0 0 0 0 7 0 40 0 0 40 0 0 0 % E
% Phe: 7 0 0 7 7 0 0 14 14 7 14 7 14 40 0 % F
% Gly: 0 0 0 0 0 14 0 0 0 0 7 0 7 0 0 % G
% His: 0 0 0 0 7 0 0 7 7 0 0 0 0 0 0 % H
% Ile: 47 40 0 7 7 7 14 14 7 47 7 7 0 0 0 % I
% Lys: 0 0 0 0 0 0 40 0 0 0 40 7 7 7 14 % K
% Leu: 7 20 7 0 7 7 20 0 7 20 7 14 0 20 60 % L
% Met: 0 7 7 0 0 0 0 0 7 0 0 7 0 7 0 % M
% Asn: 0 7 0 0 0 0 0 0 0 0 0 0 0 7 7 % N
% Pro: 7 7 7 7 7 0 0 7 0 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 7 0 0 0 0 0 0 % Q
% Arg: 7 0 40 47 0 0 7 0 7 0 0 0 7 0 0 % R
% Ser: 0 0 14 0 0 7 0 7 0 14 0 0 7 0 0 % S
% Thr: 7 0 7 0 47 7 7 47 0 0 0 7 0 0 0 % T
% Val: 7 7 0 20 14 7 0 0 0 7 14 0 14 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 0 7 7 7 0 7 0 0 0 7 7 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _