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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EGFLAM All Species: 26.06
Human Site: S228 Identified Species: 52.12
UniProt: Q63HQ2 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q63HQ2 NP_689616.2 1017 111271 S228 S H G P S P R S W P S D I I R
Chimpanzee Pan troglodytes XP_517796 1010 110654 S229 S H G P S P R S W P S D I I R
Rhesus Macaque Macaca mulatta XP_001083161 1017 111150 S228 S H G P S P R S W P S D I I R
Dog Lupus familis XP_853970 1017 112185 S228 R H G S S P R S Q R S H T I R
Cat Felis silvestris
Mouse Mus musculus Q4VBE4 1017 110717 S228 A H G F S P R S W P S N T V R
Rat Rattus norvegicus B4F785 1005 109652 S228 A Y G F S L R S Q P S N T I R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509895 380 41684
Chicken Gallus gallus XP_425019 1062 116282 S275 S Y G S S P A S T P S D V V R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001339765 1244 135834 S241 A H G I S P P S A I N N P V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611082 1361 150280 R251 T T T T T T R R S P T R A P K
Honey Bee Apis mellifera XP_393275 929 101638 S181 V S T E P A C S L D C G P A G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787979 862 94451 W113 I T G T V L Q W I R S Y L M H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.3 97.7 88 N.A. 88.4 87.5 N.A. 30.5 71.1 N.A. 48 N.A. 20.7 31.1 N.A. 30.9
Protein Similarity: 100 96.9 99 93.2 N.A. 93.2 91.6 N.A. 34.1 81.4 N.A. 62.6 N.A. 36.3 48.2 N.A. 47.9
P-Site Identity: 100 100 100 60 N.A. 66.6 53.3 N.A. 0 60 N.A. 40 N.A. 13.3 6.6 N.A. 13.3
P-Site Similarity: 100 100 100 60 N.A. 86.6 73.3 N.A. 0 80 N.A. 66.6 N.A. 40 6.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 0 0 0 0 9 9 0 9 0 0 0 9 9 0 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 9 0 34 0 0 0 % D
% Glu: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 75 0 0 0 0 0 0 0 0 9 0 0 9 % G
% His: 0 50 0 0 0 0 0 0 0 0 0 9 0 0 9 % H
% Ile: 9 0 0 9 0 0 0 0 9 9 0 0 25 42 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 0 0 0 0 17 0 0 9 0 0 0 9 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 9 25 0 0 0 % N
% Pro: 0 0 0 25 9 59 9 0 0 59 0 0 17 9 0 % P
% Gln: 0 0 0 0 0 0 9 0 17 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 59 9 0 17 0 9 0 0 67 % R
% Ser: 34 9 0 17 67 0 0 75 9 0 67 0 0 0 0 % S
% Thr: 9 17 17 17 9 9 0 0 9 0 9 0 25 0 0 % T
% Val: 9 0 0 0 9 0 0 0 0 0 0 0 9 25 0 % V
% Trp: 0 0 0 0 0 0 0 9 34 0 0 0 0 0 0 % W
% Tyr: 0 17 0 0 0 0 0 0 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _