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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WDR25
All Species:
8.79
Human Site:
S116
Identified Species:
16.11
UniProt:
Q64LD2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q64LD2
NP_001154948.1
544
60161
S116
I
K
E
P
S
C
S
S
L
W
T
S
H
V
P
Chimpanzee
Pan troglodytes
XP_001159477
546
60551
S116
I
K
E
P
S
C
S
S
L
W
T
S
H
V
P
Rhesus Macaque
Macaca mulatta
XP_001109245
270
29667
Dog
Lupus familis
XP_547980
771
84217
S340
T
G
K
P
P
P
P
S
L
W
T
S
Q
T
P
Cat
Felis silvestris
Mouse
Mus musculus
NP_808270
535
58462
V116
L
W
M
S
R
A
P
V
G
H
V
P
L
A
A
Rat
Rattus norvegicus
NP_001129366
533
58457
H116
M
N
R
A
P
V
G
H
V
P
L
A
A
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513053
427
46077
E14
Y
D
D
S
D
S
E
E
E
A
E
T
A
R
I
Chicken
Gallus gallus
XP_426463
507
56489
S94
S
Y
C
R
R
V
Y
S
S
P
T
A
L
R
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23256
501
54455
Q88
P
Y
Q
S
H
Q
Q
Q
F
H
P
L
A
I
A
Sea Urchin
Strong. purpuratus
XP_788503
400
44994
Poplar Tree
Populus trichocarpa
XP_002319259
408
45567
Maize
Zea mays
NP_001147634
445
48986
S32
P
V
A
T
R
S
A
S
F
S
P
P
P
M
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_200263
457
50597
E44
K
R
P
Y
P
V
P
E
E
R
Q
Y
K
P
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
45.2
54.3
N.A.
77.7
76.8
N.A.
27
49.8
N.A.
N.A.
N.A.
N.A.
N.A.
20.9
31.4
Protein Similarity:
100
95.4
47
62
N.A.
84.9
84.5
N.A.
39.3
64.8
N.A.
N.A.
N.A.
N.A.
N.A.
39.1
46.3
P-Site Identity:
100
100
0
46.6
N.A.
0
0
N.A.
0
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
100
0
53.3
N.A.
6.6
20
N.A.
13.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
0
Percent
Protein Identity:
30.5
29.7
N.A.
29
N.A.
N.A.
Protein Similarity:
46.8
45.7
N.A.
47.4
N.A.
N.A.
P-Site Identity:
0
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
0
20
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
8
8
0
0
8
0
16
24
16
16
% A
% Cys:
0
0
8
0
0
16
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
8
8
0
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
16
0
0
0
8
16
16
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
8
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
8
0
16
0
0
16
0
0
% H
% Ile:
16
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% I
% Lys:
8
16
8
0
0
0
0
0
0
0
0
0
8
0
8
% K
% Leu:
8
0
0
0
0
0
0
0
24
0
8
8
16
0
0
% L
% Met:
8
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
16
0
8
24
24
8
24
0
0
16
16
16
8
8
31
% P
% Gln:
0
0
8
0
0
8
8
8
0
0
8
0
8
0
0
% Q
% Arg:
0
8
8
8
24
0
0
0
0
8
0
0
0
16
0
% R
% Ser:
8
0
0
24
16
16
16
39
8
8
0
24
0
0
0
% S
% Thr:
8
0
0
8
0
0
0
0
0
0
31
8
0
8
0
% T
% Val:
0
8
0
0
0
24
0
8
8
0
8
0
0
16
8
% V
% Trp:
0
8
0
0
0
0
0
0
0
24
0
0
0
0
0
% W
% Tyr:
8
16
0
8
0
0
8
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _