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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WDR25 All Species: 8.48
Human Site: S140 Identified Species: 15.56
UniProt: Q64LD2 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q64LD2 NP_001154948.1 544 60161 S140 R F K Q V K L S R N F P K S S
Chimpanzee Pan troglodytes XP_001159477 546 60551 S140 R F K Q V K L S R N F P K S S
Rhesus Macaque Macaca mulatta XP_001109245 270 29667
Dog Lupus familis XP_547980 771 84217 S364 H F R R M K L S W G T Y D S P
Cat Felis silvestris
Mouse Mus musculus NP_808270 535 58462 H140 W D V L K P S H D Q S T F E S
Rat Rattus norvegicus NP_001129366 533 58457 H140 A F T P S H T H S K L E S T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513053 427 46077 S38 Q G S L G L P S V P G R S T V
Chicken Gallus gallus XP_426463 507 56489 N118 S S S R N S G N G A S Q K R T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23256 501 54455 P112 Q V I Y P P P P P G F T P H R
Sea Urchin Strong. purpuratus XP_788503 400 44994 D11 Q V P V N Q Q D P L L N Q Q C
Poplar Tree Populus trichocarpa XP_002319259 408 45567 E19 S D E E P E P E P E S E S K P
Maize Zea mays NP_001147634 445 48986 P56 L P P T H C F P Q P P L P D A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_200263 457 50597 S68 Y S E S Q T S S S F S I P V P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.8 45.2 54.3 N.A. 77.7 76.8 N.A. 27 49.8 N.A. N.A. N.A. N.A. N.A. 20.9 31.4
Protein Similarity: 100 95.4 47 62 N.A. 84.9 84.5 N.A. 39.3 64.8 N.A. N.A. N.A. N.A. N.A. 39.1 46.3
P-Site Identity: 100 100 0 33.3 N.A. 6.6 6.6 N.A. 6.6 6.6 N.A. N.A. N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 100 0 53.3 N.A. 6.6 20 N.A. 20 26.6 N.A. N.A. N.A. N.A. N.A. 13.3 20
Percent
Protein Identity: 30.5 29.7 N.A. 29 N.A. N.A.
Protein Similarity: 46.8 45.7 N.A. 47.4 N.A. N.A.
P-Site Identity: 0 0 N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 13.3 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 16 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 16 0 0 0 0 0 8 8 0 0 0 8 8 0 % D
% Glu: 0 0 16 8 0 8 0 8 0 8 0 16 0 8 0 % E
% Phe: 0 31 0 0 0 0 8 0 0 8 24 0 8 0 0 % F
% Gly: 0 8 0 0 8 0 8 0 8 16 8 0 0 0 0 % G
% His: 8 0 0 0 8 8 0 16 0 0 0 0 0 8 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 16 0 8 24 0 0 0 8 0 0 24 8 0 % K
% Leu: 8 0 0 16 0 8 24 0 0 8 16 8 0 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 16 0 0 8 0 16 0 8 0 0 0 % N
% Pro: 0 8 16 8 16 16 24 16 24 16 8 16 24 0 24 % P
% Gln: 24 0 0 16 8 8 8 0 8 8 0 8 8 8 0 % Q
% Arg: 16 0 8 16 0 0 0 0 16 0 0 8 0 8 8 % R
% Ser: 16 16 16 8 8 8 16 39 16 0 31 0 24 24 24 % S
% Thr: 0 0 8 8 0 8 8 0 0 0 8 16 0 16 8 % T
% Val: 0 16 8 8 16 0 0 0 8 0 0 0 0 8 8 % V
% Trp: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 8 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _