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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPZ All Species: 8.18
Human Site: S524 Identified Species: 25.71
UniProt: Q66K79 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q66K79 NP_001014447.1 652 73655 S524 P V K N A R I S V K G I R H D
Chimpanzee Pan troglodytes A5A6K7 476 53027 K377 E Q I H R G V K G F V R D L Q
Rhesus Macaque Macaca mulatta XP_001097378 620 69212 G519 Y L E Q I H R G V K G F V R D
Dog Lupus familis XP_545910 701 78267 L450 P V K N A R I L V K G I R H D
Cat Felis silvestris
Mouse Mus musculus Q8R4V4 654 73676 L529 P V K N A R I L V K G I R H D
Rat Rattus norvegicus O54858 652 73063 L527 P V K N A R I L V K G I R H D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q8QGP3 647 73900 S521 P I K N A R I S V R G I Q H D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_685713 653 74485 S528 G I K G A I I S V K G L R H D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 38.6 36 70.6 N.A. 81 82.6 N.A. N.A. 65.4 N.A. 56.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 49.6 50.1 74.8 N.A. 88.3 89.4 N.A. N.A. 79.1 N.A. 73.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 26.6 93.3 N.A. 93.3 93.3 N.A. N.A. 80 N.A. 66.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 40 93.3 N.A. 93.3 93.3 N.A. N.A. 100 N.A. 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 75 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 88 % D
% Glu: 13 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 13 0 13 0 0 0 % F
% Gly: 13 0 0 13 0 13 0 13 13 0 88 0 0 0 0 % G
% His: 0 0 0 13 0 13 0 0 0 0 0 0 0 75 0 % H
% Ile: 0 25 13 0 13 13 75 0 0 0 0 63 0 0 0 % I
% Lys: 0 0 75 0 0 0 0 13 0 75 0 0 0 0 0 % K
% Leu: 0 13 0 0 0 0 0 38 0 0 0 13 0 13 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 63 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 13 0 13 0 0 0 0 0 0 0 0 13 0 13 % Q
% Arg: 0 0 0 0 13 63 13 0 0 13 0 13 63 13 0 % R
% Ser: 0 0 0 0 0 0 0 38 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 50 0 0 0 0 13 0 88 0 13 0 13 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _