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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R2D
All Species:
51.21
Human Site:
Y250
Identified Species:
93.89
UniProt:
Q66LE6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q66LE6
NP_001003656.1
453
52042
Y250
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Chimpanzee
Pan troglodytes
XP_521665
464
53541
Y261
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Rhesus Macaque
Macaca mulatta
XP_001091436
453
51968
Y250
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Dog
Lupus familis
XP_548708
443
51417
Y240
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Cat
Felis silvestris
Mouse
Mus musculus
Q925E7
453
51939
Y250
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Rat
Rattus norvegicus
P56932
453
51964
Y250
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZIY5
451
51997
Y248
H
H
C
N
V
F
V
Y
S
S
S
K
G
T
I
Frog
Xenopus laevis
A1L3L9
468
54505
Y265
H
N
C
N
T
F
V
Y
S
S
S
K
G
T
I
Zebra Danio
Brachydanio rerio
NP_998045
447
51698
Y244
H
Q
C
N
V
F
V
Y
S
S
S
K
G
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P36872
499
56948
Y297
T
E
C
N
V
F
V
Y
S
S
S
K
G
T
I
Honey Bee
Apis mellifera
XP_394082
443
50862
Y241
A
E
C
N
V
L
V
Y
S
S
S
K
G
T
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39247
501
56256
Y289
I
H
C
N
M
L
A
Y
S
S
S
K
G
S
I
Baker's Yeast
Sacchar. cerevisiae
Q00362
526
59644
Y251
Q
E
C
N
L
F
M
Y
S
S
S
K
G
T
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.8
99.5
91.1
N.A.
97.3
96.6
N.A.
N.A.
95.3
80.5
94
N.A.
70.3
80.5
N.A.
N.A.
Protein Similarity:
100
92.8
99.7
93.5
N.A.
99.3
98.9
N.A.
N.A.
98
88.8
97.3
N.A.
81.1
90
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
86.6
100
N.A.
86.6
80
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
86.6
100
N.A.
93.3
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
50.9
47.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66.4
64.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
73.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
85
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% G
% His:
70
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% K
% Leu:
0
0
0
0
8
16
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
100
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
54
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
100
100
100
0
0
8
0
% S
% Thr:
8
0
0
0
8
0
0
0
0
0
0
0
0
93
0
% T
% Val:
0
0
0
0
77
0
85
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _