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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF
All Species:
10.3
Human Site:
S112
Identified Species:
18.89
UniProt:
Q68CQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q68CQ4
NP_055203.4
756
87055
S112
M
N
D
E
D
G
G
S
D
V
S
V
E
E
E
Chimpanzee
Pan troglodytes
XP_525053
756
87125
S112
M
N
D
E
D
G
G
S
D
V
S
V
E
E
E
Rhesus Macaque
Macaca mulatta
XP_001109922
755
86704
S111
M
N
D
E
G
G
G
S
D
V
S
V
E
E
E
Dog
Lupus familis
XP_547394
639
73475
S48
F
T
D
A
K
H
E
S
L
F
S
L
E
T
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTT6
772
88799
A112
E
E
E
E
D
D
S
A
V
G
D
A
E
M
N
Rat
Rattus norvegicus
Q5M9G7
763
87806
E112
D
S
A
V
G
D
S
E
M
N
G
E
D
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509371
772
89238
A114
E
S
I
L
G
D
E
A
E
V
D
N
E
G
D
Chicken
Gallus gallus
Q5ZLG3
772
88932
Q110
E
L
D
S
E
G
S
Q
E
P
K
E
A
V
G
Frog
Xenopus laevis
NP_001091284
767
88492
E113
E
E
L
H
E
E
S
E
A
E
N
E
D
K
E
Zebra Danio
Brachydanio rerio
Q6PEH4
753
86784
E110
V
E
G
D
S
E
E
E
V
E
D
T
D
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611851
700
81542
I109
V
I
P
V
P
R
K
I
K
P
K
K
E
K
R
Honey Bee
Apis mellifera
XP_395073
700
81460
K108
Q
L
D
N
K
D
E
K
V
D
S
T
S
D
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40498
721
83973
E120
E
D
E
H
E
N
T
E
H
G
P
V
D
D
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.7
78
N.A.
86.2
87.8
N.A.
74.3
68.9
68
54.5
N.A.
35.3
42.2
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
81.3
N.A.
91.1
93.3
N.A.
85.6
81.3
82
71
N.A.
56.3
62.8
N.A.
N.A.
P-Site Identity:
100
100
93.3
26.6
N.A.
20
0
N.A.
13.3
13.3
6.6
13.3
N.A.
6.6
20
N.A.
N.A.
P-Site Similarity:
100
100
93.3
33.3
N.A.
33.3
13.3
N.A.
40
26.6
33.3
33.3
N.A.
20
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
0
16
8
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
47
8
24
31
0
0
24
8
24
0
31
16
8
% D
% Glu:
39
24
16
31
24
16
31
31
16
16
0
24
54
31
47
% E
% Phe:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
8
0
24
31
24
0
0
16
8
0
0
16
16
% G
% His:
0
0
0
16
0
8
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
16
0
8
8
8
0
16
8
0
16
0
% K
% Leu:
0
16
8
8
0
0
0
0
8
0
0
8
0
0
0
% L
% Met:
24
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% M
% Asn:
0
24
0
8
0
8
0
0
0
8
8
8
0
0
16
% N
% Pro:
0
0
8
0
8
0
0
0
0
16
8
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
16
0
8
8
0
31
31
0
0
39
0
8
0
0
% S
% Thr:
0
8
0
0
0
0
8
0
0
0
0
16
0
8
0
% T
% Val:
16
0
0
16
0
0
0
0
24
31
0
31
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _