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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF
All Species:
13.64
Human Site:
S182
Identified Species:
25
UniProt:
Q68CQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q68CQ4
NP_055203.4
756
87055
S182
E
E
S
G
D
N
S
S
L
K
A
S
Q
D
P
Chimpanzee
Pan troglodytes
XP_525053
756
87125
S182
E
E
S
G
D
N
S
S
L
K
A
S
Q
D
P
Rhesus Macaque
Macaca mulatta
XP_001109922
755
86704
S181
E
E
S
G
D
N
S
S
L
K
A
S
Q
D
P
Dog
Lupus familis
XP_547394
639
73475
T118
S
K
F
Q
K
L
E
T
F
K
P
S
K
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTT6
772
88799
F182
D
V
K
H
E
S
L
F
S
L
E
T
N
F
L
Rat
Rattus norvegicus
Q5M9G7
763
87806
S182
T
N
F
L
E
E
E
S
G
G
S
Y
S
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509371
772
89238
E184
L
E
T
N
F
L
E
E
K
N
E
D
H
N
K
Chicken
Gallus gallus
Q5ZLG3
772
88932
M180
F
S
L
E
T
N
F
M
E
E
E
S
G
D
C
Frog
Xenopus laevis
NP_001091284
767
88492
D183
S
L
E
T
N
F
L
D
A
D
N
E
D
S
K
Zebra Danio
Brachydanio rerio
Q6PEH4
753
86784
G180
E
T
N
M
P
A
E
G
E
E
N
T
A
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611851
700
81542
P179
L
T
E
D
F
K
E
P
D
C
S
E
P
K
D
Honey Bee
Apis mellifera
XP_395073
700
81460
I178
W
P
V
L
G
N
L
I
C
E
I
S
K
S
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40498
721
83973
S190
T
K
S
V
K
Y
K
S
V
K
G
S
L
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.7
78
N.A.
86.2
87.8
N.A.
74.3
68.9
68
54.5
N.A.
35.3
42.2
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
81.3
N.A.
91.1
93.3
N.A.
85.6
81.3
82
71
N.A.
56.3
62.8
N.A.
N.A.
P-Site Identity:
100
100
100
20
N.A.
0
6.6
N.A.
6.6
20
0
6.6
N.A.
0
13.3
N.A.
N.A.
P-Site Similarity:
100
100
100
40
N.A.
26.6
20
N.A.
20
26.6
6.6
26.6
N.A.
6.6
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
8
0
24
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
8
% C
% Asp:
8
0
0
8
24
0
0
8
8
8
0
8
8
39
16
% D
% Glu:
31
31
16
8
16
8
39
8
16
24
24
16
0
0
0
% E
% Phe:
8
0
16
0
16
8
8
8
8
0
0
0
0
8
8
% F
% Gly:
0
0
0
24
8
0
0
8
8
8
8
0
8
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% I
% Lys:
0
16
8
0
16
8
8
0
8
39
0
0
16
8
16
% K
% Leu:
16
8
8
16
0
16
24
0
24
8
0
0
8
0
8
% L
% Met:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
8
39
0
0
0
8
16
0
8
8
0
% N
% Pro:
0
8
0
0
8
0
0
8
0
0
8
0
8
0
24
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
24
16
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
16
8
31
0
0
8
24
39
8
0
16
54
8
24
0
% S
% Thr:
16
16
8
8
8
0
0
8
0
0
0
16
0
0
0
% T
% Val:
0
8
8
8
0
0
0
0
8
0
0
0
0
0
8
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _