KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF
All Species:
16.06
Human Site:
S246
Identified Species:
29.44
UniProt:
Q68CQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q68CQ4
NP_055203.4
756
87055
S246
P
K
D
I
D
L
K
S
L
H
L
Q
K
P
L
Chimpanzee
Pan troglodytes
XP_525053
756
87125
S246
P
K
D
I
D
L
K
S
L
H
L
Q
K
P
L
Rhesus Macaque
Macaca mulatta
XP_001109922
755
86704
S245
P
K
D
I
D
L
K
S
L
H
L
Q
K
P
L
Dog
Lupus familis
XP_547394
639
73475
L175
I
M
N
S
Y
Q
D
L
F
Y
P
E
R
T
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTT6
772
88799
L262
P
K
D
I
D
L
K
L
L
H
L
Q
K
P
L
Rat
Rattus norvegicus
Q5M9G7
763
87806
S251
P
K
D
I
D
L
K
S
L
H
L
Q
K
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509371
772
89238
E263
P
K
E
V
N
V
K
E
L
T
L
Q
K
P
L
Chicken
Gallus gallus
Q5ZLG3
772
88932
L262
K
E
F
S
V
K
Q
L
Y
L
H
K
P
L
E
Frog
Xenopus laevis
NP_001091284
767
88492
L258
K
P
E
K
E
P
D
L
H
K
L
Y
L
H
K
Zebra Danio
Brachydanio rerio
Q6PEH4
753
86784
A243
R
F
P
A
I
G
Q
A
S
S
A
P
L
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611851
700
81542
N236
Y
P
H
R
T
H
G
N
A
E
D
I
R
Y
V
Honey Bee
Apis mellifera
XP_395073
700
81460
Y235
I
N
N
Y
Q
D
L
Y
Y
P
E
R
T
F
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40498
721
83973
T248
D
K
K
T
D
P
L
T
A
L
Q
K
K
L
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.7
78
N.A.
86.2
87.8
N.A.
74.3
68.9
68
54.5
N.A.
35.3
42.2
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
81.3
N.A.
91.1
93.3
N.A.
85.6
81.3
82
71
N.A.
56.3
62.8
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
93.3
100
N.A.
60
0
6.6
6.6
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
100
N.A.
86.6
20
20
20
N.A.
20
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
16
0
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
39
0
47
8
16
0
0
0
8
0
0
0
0
% D
% Glu:
0
8
16
0
8
0
0
8
0
8
8
8
0
0
8
% E
% Phe:
0
8
8
0
0
0
0
0
8
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
8
0
0
8
39
8
0
0
8
0
% H
% Ile:
16
0
0
39
8
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
16
54
8
8
0
8
47
0
0
8
0
16
54
0
8
% K
% Leu:
0
0
0
0
0
39
16
31
47
16
54
0
16
16
47
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
16
0
8
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
47
16
8
0
0
16
0
0
0
8
8
8
8
54
8
% P
% Gln:
0
0
0
0
8
8
16
0
0
0
8
47
0
0
0
% Q
% Arg:
8
0
0
8
0
0
0
0
0
0
0
8
16
0
0
% R
% Ser:
0
0
0
16
0
0
0
31
8
8
0
0
0
0
8
% S
% Thr:
0
0
0
8
8
0
0
8
0
8
0
0
8
8
0
% T
% Val:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
8
0
0
8
16
8
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _